Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-1841	Belizatinib (TSR011) CAS：1357920-84-3	Belizatinib is an oral,dual,potent inhibitor of ALK and TRKA,TRKB,and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.	price>
R-C-1842	H3B-6527 CAS：1702259-66-2	H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3(IC50 values of 320,1,290 and 1,060nM respectively).	price>
R-C-1845	SGI7079 CAS:1239875-86-5	SGI-7079,a novel selective Axl inhibitor with an IC50 of 58 nM in vitro, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.	price>
R-C-1853	DBPR114 CAS：2443767-35-7	DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases,including Aurora-A,FLT3,CSF1R,MET,etc.DBPR114 exhibited favorable PK profiles:a long half-life(t1/2 =23.5h),moderate clearance and high volume of distribution.Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11,MIA PaCa-2,Hep3B, MKN45,Colo205,and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.	price>
R-C-1863	Vecabrutinib (SNS-062) CAS:1510829-06-7	Vecabrutinib(SNS-062)is a potent,noncovalent BTK and ITK inhibitor, with Kd values of 0.3 nM and 2.2nM,respectively.Vecabrutinib shows an IC50 of 24 nM for ITK.	price>
R-C-1864	BAY 61-3606 CAS:732983-37-8	BAY 61-3606 is an orally available,ATP-competitive,reversible and highly selective Syk inhibitor with a Ki of 7.5nM and an IC50 of 10nM.BAY 61-3606 reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell.BAY 61-3606 induces a large decrease of Syk phosphorylation in K-rn cell lysates.Bay 61-3606 sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.	price>
R-C-1868	PRT-060318(PRT318) CAS:1194961-19-7	PRT-060318(PRT318)is a novel selective inhibitor of the tyrosine kinase Syk with an IC50 of 4nM.	price>
R-C-1882	Evobrutinib (M-2951) CAS:1415823-73-2	Evobrutinib(M-2951,MSC-2364447C)is a highly selective BTK inhibitor with an IC50 of 37.9 nM.It has potential anti-neoplastic activity.	price>
R-C-2254	LM22B-10 CAS：342777-54-2	LM22B-10 is a TrkB and TrkC agonist.LM22B-10 exhibits neurotrophic activity .	price>
R-C-1909	AD 80 CAS：1384071-99-1	AD80,a multikinase inhibitor,shows strong activity against human RET(c-RET),BRAF,S6K,and SRC but were much less active than either AD57 or AD58 against mTOR.The IC50 value for RET is 4nM.	price>

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