Catalog |
name |
Description |
price |
R-C-2061 |
Glumetinib CAS:1642581-63-2 |
Glumetinib(SCC244)is a potent and highly selective c-Met inhibitor with an IC50 of 0.42±0.02 nmol/L.Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated,including the c-Met family member RON and highly homologous kinases Axl,Mer,and TyrO3. |
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R-C-2064 |
PLX5622 CAS:1303420-67-8 |
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM,for extended and specific microglial elimination,preceding and during pathology development. |
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R-C-2071 |
Branebrutinib (BMS-986195) CAS:1912445-55-6 |
Branebrutinib(BMS-986195)is a highly potent,selective covalent,irreversible inhibitor of Bruton is tyrosine kinase(BTK),with an IC50 of 0.1nM. |
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R-C-2076 |
SU14813 CAS: 627908-92-3 |
SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50,2,4,15 nM for VEGFR2,VEGFR1,PDGFRβ and KIT. |
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R-C-2080 |
Bemcentinib (R428) CAS:1037624-75-1 |
Bemcentinib(R428,BGB324)is an inhibitor of Axl with IC50 of 14 nM,>100-fold selective for Axl versus Abl.Selectivty for Axl is also greater than Mer and Tyro3(50-to-100- fold more selective)and InsR,EGFR,HER2,and PDGFRβ(100- fold more selective). |
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R-C-2128 |
Olmutinib (BI 1482694) CAS:1353550-13-6 |
Olmutinib(BI 1482694)is a novel third-generation epidermal growth factor receptor(EGFR)mutation-specific tyrosine kinase inhibitor(TKI).Also a potent inhibitor of Bruton is tyrosine kinase. |
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R-C-2178 |
Apatinib CAS:811803-05-1 |
Apatinib(Rivoceranib,YN968D1)is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1nM,13nM,429nM and 530nM for VEGFR-2,Ret(c-Ret),c-Kit and c-Src,respectively.Apatinib induces both autophagy and apoptosis. |
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R-C-2179 |
Axitinib (AG 013736) CAS:319460-85-0 |
Axitinib(AG013736)is an orally bioavailable tyrosine kinase inhibitor.Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor(VEGF)and platelet-derived growth factor receptor(PDGF),thereby exerting an anti-angiogenic effect. |
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R-C-2180 |
Nintedanib (BIBF 1120) CAS:656247-17-5 |
Nintedanib(BIBF 1120)is a potent triple angiokinase inhibitor for VEGFR1/2/3,FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13nM/13nM,69 nM/37nM/108nM and 59nM/65nM,respectively. |
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R-C-2181 |
Cediranib(AZD2171) CAS:288383-20-0 |
Cediranib(AZD2171,NSC-732208)is a highly potent VEGFR(KDR)inhibitor with IC50 of<1nM,also inhibits Flt1/4 with IC50 of 5 nM/≤3nM,similar activity against c-Kit and PDGFRβ,36-,110-fold and >1000-fold selective more for VEGFR than PDGFR-α,CSF-1R and Flt3 in HUVEC cells.Cediranib(AZD2171) induces autophagic vacuole accumulation. |
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