Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-2064	PLX5622 CAS：1303420-67-8	PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM,for extended and specific microglial elimination,preceding and during pathology development.	price>
R-C-2071	Branebrutinib (BMS-986195) CAS：1912445-55-6	Branebrutinib(BMS-986195)is a highly potent,selective covalent,irreversible inhibitor of Bruton is tyrosine kinase(BTK),with an IC50 of 0.1nM.	price>
R-C-2076	SU14813 CAS： 627908-92-3	SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC50s of 50,2,4,15 nM for VEGFR2,VEGFR1,PDGFRβ and KIT.	price>
R-C-2080	Bemcentinib (R428) CAS：1037624-75-1	Bemcentinib(R428,BGB324)is an inhibitor of Axl with IC50 of 14 nM,>100-fold selective for Axl versus Abl.Selectivty for Axl is also greater than Mer and Tyro3(50-to-100- fold more selective)and InsR,EGFR,HER2,and PDGFRβ(100- fold more selective).	price>
R-C-2128	Olmutinib (BI 1482694) CAS：1353550-13-6	Olmutinib(BI 1482694)is a novel third-generation epidermal growth factor receptor(EGFR)mutation-specific tyrosine kinase inhibitor(TKI).Also a potent inhibitor of Bruton is tyrosine kinase.	price>
R-C-2178	Apatinib CAS:811803-05-1	Apatinib(Rivoceranib,YN968D1)is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1nM,13nM,429nM and 530nM for VEGFR-2,Ret(c-Ret),c-Kit and c-Src,respectively.Apatinib induces both autophagy and apoptosis.	price>
R-C-2179	Axitinib (AG 013736) CAS:319460-85-0	Axitinib(AG013736)is an orally bioavailable tyrosine kinase inhibitor.Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor(VEGF)and platelet-derived growth factor receptor(PDGF),thereby exerting an anti-angiogenic effect.	price>
R-C-2180	Nintedanib (BIBF 1120) CAS:656247-17-5	Nintedanib(BIBF 1120)is a potent triple angiokinase inhibitor for VEGFR1/2/3,FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13nM/13nM,69 nM/37nM/108nM and 59nM/65nM,respectively.	price>
R-C-2181	Cediranib(AZD2171) CAS:288383-20-0	Cediranib(AZD2171,NSC-732208)is a highly potent VEGFR(KDR)inhibitor with IC50 of<1nM,also inhibits Flt1/4 with IC50 of 5 nM/≤3nM,similar activity against c-Kit and PDGFRβ,36-,110-fold and >1000-fold selective more for VEGFR than PDGFR-α,CSF-1R and Flt3 in HUVEC cells.Cediranib(AZD2171) induces autophagic vacuole accumulation.	price>
R-C-2182	Dovitinib (TKI-258) CAS:405169-16-6	Dovitinib(CHIR-258)is a multi-targeted tyrosine kinase inhibitor with IC50s of 1,2,8/9,10/13/8,27/210 nM for FLT3,c-Kit,FGFR1/FGFR3,VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ.	price>

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