Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-2207	SU5205 CAS:3476-86-6	SU5205 is an inhibitor of VEGFR2 (FLK-1),with an IC50 of 9.6μM.	price>
R-C-2209	CS-2660 (JNJ-38158471) CAS:951151-97-6	CS-2660(JNJ-38158471)is a well tolerated,orally available,highly selective VEGFR-2 inhibitor with IC50 of 40 nM.CS-2660(JNJ-38158471)also inhibits closely related tyrosine kinases such as RET(c-RET)and Kit(c-Kit)with IC50 of 180nM and 500nMwhile it has no significant activity(>1 microM) against VEGFR-1 and VEGFR-3.	price>
R-C-2210	Ningetinib CAS:1394820-69-9	Ningetinib is a potent,orally bioavailable small molecule tyrosine kinase inhibitor(TKI)with IC50s of 6.7,1.9 and<1.0nM for c-Met,VEGFR2 and Axl,respectively.	price>
R-C-2212	AG-13958 CAS:319460-94-1	AG-13958(AG-013958),a potent VEGFR tyrosine kinase inhibitor,is used for treatment of choroidal neovascularization associated with age-related macular degeneration(AMD).	price>
R-C-2214	SKLB 610 CAS:1125780-41-7	SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2,fibroblast growth factor receptor 2(FGFR2)and platelet-derived growth factor receptor(PDGFR)at rate of 97%,65% and 55%,respectively,at concentration of 10μM in biochemical kinase assays.SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity.	price>
R-C-2215	MAZ51 CAS:163655-37-6	MAZ51 is a potent and selective inhibitor of vascular endothelial growth factor receptor(VEGFR)-3(Flt-4)tyrosine kinase.MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells through phosphorylation of Akt/GSK3β and activation of RhoA.MAZ51 inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.	price>
R-C-2216	SU5204 CAS:186611-11-0	SU5204,a tyrosine kinase inhibitor,has IC50s of 4 and 51.5μM for FLK-1(VEGFR-2)and HER2,respectively.	price>
R-C-2483	AMG-208 CAS:1002304-34-8	AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity.c-Met inhibitor AMG 208 inhibits the ligand-dependent and ligand-independent activation of c-Met,inhibiting its tyrosine kinase activity,which may result in cell growth inhibition in tumors that overexpress c-Met.	price>
R-C-2499	Varlitinib (ARRY334543) CAS：845272-21-1	Varlitinib(ASLAN001)is a potent,reversible,small molecule pan-EGFR inhibitor with IC50s of 7,2,4nM for HER1,HER2 and HER4,respectively.	price>
R-C-2555	BPR1J-097 CAS:1327167-19-0	BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities.BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells.BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.	price>

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