Product apis-protein-tyrosine-kinase

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Catalog	name	Description	price
R-C-2182	Dovitinib (TKI-258) CAS:405169-16-6	Dovitinib(CHIR-258)is a multi-targeted tyrosine kinase inhibitor with IC50s of 1,2,8/9,10/13/8,27/210 nM for FLT3,c-Kit,FGFR1/FGFR3,VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ.	price>
R-C-2183	OSI-930 CAS：728033-96-3	OSI-930 is an orally selective inhibitor of Kit,KDR and CSF-1R (c-Fms)with IC50s of 80 nM,9nM and 15nM,respectively.OSI-930 also moderately inhibits Flt-1,c-Raf,Lck and low activity against PDGFRα/β,Flt-3 and Abl. OSI-930 has antitumor activity.	price>
R-C-2184	KRN 633 CAS：286370-15-8	KRN 633 is a cell-permeable,reversible,ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only(IC50=0.97μM and 4.33μM,respectively)and inactive towards 17 other kinases(IC50≥10μM).	price>
R-C-2185	Alectinib (CH5424802) CAS: 1256580-46-7	Alectinib(CH5424802)is a potent,selective,and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4nM(in an ATP-competitive manner),and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1nM and 3.5 nM,respectively.Alectinib demonstrates effective central nervous system(CNS) penetration.	price>
R-C-2186	AP26113-analog (ALK-IN-1)	AP26113 is an orally-available,potent,and selective inhibitor of ALK with a potency of 0.62nM against wild-type and activity against a wide range of mutants,including the crizotinib-resistant L1196M line.In a panel of EML4-ALK or NPM-ALK-positive cell lines,AP26113 has IC50 values of 4-31 nM.AP26113 is effective against sensitive and resistant H3122 cells,reducing cell growth, suppressing ALK phosphorylation,and inducing apoptosis.	price>
R-C-2187	Ceritinib dihydrochloride CAS:1380575-43-8	Ceritinib dihydrochloride(LDK378 dihydrochloride)is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM.Ceritinib dihydrochloride(LDK378 dihydrochloride)also inhibits IGF-1R,InsR,and STK22D with IC50 values of 8,7,and 23nM,respectively.Ceritinib dihydrochloride(LDK378 dihydrochloride)shows great antitumor potency.	price>
R-C-2202	Ramucirumab (anti-VEGFR2) CAS:947687-13-0	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands:VEGF-A,VEGF-C,and VEGF-D.	price>
R-C-2203	Sulfatinib CAS:1308672-74-3	Sulfatinib(HMPL-012)is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3,FGFR1 and CSF1R with IC50s of in a range of 1 to 24nM.	price>
R-C-2205	SU5214 CAS: 186611-04-1	SU5214 is a potent VEGFR2 inhibitor extracted from patent US5834504A,SU5214, has IC50s of 14.8µM(FLK-1)and 36.7µM(EGFR),respectively.	price>
R-C-2206	SU5408 CAS:15966-93-5	SU5408(VEGFR2 Kinase Inhibitor I)is a potent and cell-permeable inhibitor of VEGFR2 kinase with an IC50 of 70nM.	price>

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