Product apis-metabolism

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Catalog	name	Description	price
R-C-1871	Tropifexor (LJN452) CAS:1383816-29-2	Tropifexor(LJN452)is a novel and highly potent agonist of FXR with EC50 of 0.2 nM in HTRF assay.It shows no significant off-target activity against a broad panel of enzyme,ion channel,nuclear receptor,and GPCR(>10000-fold selectivity for FXR).	price>
R-C-1877	Ziritaxestat (GLPG1690) CAS:1628260-79-6	Ziritaxestat(GLPG1690)is a first-in-class autotaxin(ATX)inhibitor,with an IC50 of 131 nM and Ki of 15nnM.	price>
R-C-1879	KPT9274 CAS:1643913-93-2	KPT 9274(ATG-019)is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT.It shows an IC50 of~120nM for NAMPT in a cell-free enzymatic assay.	price>
R-C-1881	ML355 CAS:1532593-30-8	ML355 is a potent and selective inhibitor of 12-Lipoxygenase(12-LOX)with an IC50 of 0.34μM,shows excellent selectivity over related lipoxygenases and cyclooxygenases,and possesses favorable ADME properties.	price>
R-C-1925	PF05175157 CAS：1301214-47-0	PF-05175157 is a potent and selective cetyl-CoA carboxylase(ACC)1 and 2 inhibitor with IC50 values of 27nM and 33 nM,respectively.PF-05175157 led to robust reduction of de novo lipogenesis(DNL),albeit with concomitant reductions in platelet count,which were attributed to the inhibition of fatty acid synthesis within bone marrow.PF-05175157 induced a reduction of the viral load in serum and kidney in WNV-infected mice,unveiling its therapeutic potential for the treatment of chronic kidney disease associated with persistent WNV infection.	price>
R-C-1926	PF06291874 CAS：1393124-08- 7	PF-06291874(Glucagon receptor antagonists-4)is a highly potent and orally active glucagon receptor antagonist.It displays low in vivo clearance in both rats and dogs.	price>
R-C-1928	Tipifarnib S enantiomer CAS：192185-71-0	Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib.Tipifarnib is a potent and specific farnesyltransferase(FTase)inhibitor with IC50 of 0.6nM.Tipifarnib S enantiomer is the less active isomer.	price>
R-C-1935	RRx-001 CAS:925206-65-1	RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity.It inhibits glucose 6-phosphate dehydrogenase(G6PD)in human tumor cells,binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. RRx-001 triggers apoptosis and exhibits anticancer activity.	price>
R-C-1941	VU0155069 (CAY10593) CAS：1130067-06-9	VU0155069(CAY10593),compound 69,is a selective phospholipase D1(PLD1)inhibitor with an IC50 value of 46 nM in vitro.VU0155069(CAY10593)strongly inhibits the invasive migration of several cancer cell lines in transwell assays.	price>
R-C-1954	PKM2 inhibitor(compound 3k) CAS:94164-88-2	PKM2 inhibitor(Compound 3K)displays PKM2 inhibitory activity with the IC50 value of 2.95μM.The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.	price>

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