Product apis-metabolism

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Catalog	name	Description	price
R-C-1964	Nidufexor（LMB-763） CAS:1773489-72-7	Nidufexor(LMB763)is an orally-available farnesoid X receptor(FXR)agonist for the research of nonalcoholic steatohepatitis(NASH).	price>
R-C-1980	Linrodostat (BMS-986205) CAS No. 1923833-60-6	Linrodostat（BMS-986205, ONO-7701 and F001287)a potent and selective,orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.BMS-986205 specifically targets and binds to IDO1,a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine.By inhibiting IDO1 and decreasing kynurenine in tumor cells,BMS-986205 restores and promotes the proliferation and activation of various immune cells,including dendritic cells(DCs),natural killer (NK)cells,and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells(Tregs).	price>
R-C-1982	Chr-2797 CAS：238750-77-1	Tosedostat(CHR-2797)is an orally active aminopeptidase inhibitor.CHR-2797 exerts antiproliferative effects against a range of tumor cell lines.	price>
R-C-1986	Elafibranor(GFT505） CAS：923978-27-2	Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α)and peroxisome proliferator-activated receptor-δ(PPAR-δ)with EC50 values of 45 and 175 nM.	price>
R-C-1987	JQZ5 CAS 1913252-04-6	JQEZ5 is an inhibitor of EZH2 lysine methyltransferase(IC50=11.1nM).	price>
R-C-1988	Alrestatin CAS：51411-04-2	Alrestatin is an inhibitor of aldose reductase,an enzyme involved in the pathogenesis of complications of diabetes mellitus,including diabetic neuropathy.	price>
R-C-1999	SR0987 CAS;303126-97-8	SR0987,a SR1078 analog,is a RORγt agonist,with an EC50 of 800nM.SR0987 increases IL17 expression while repressing the expression of PD-1.	price>
R-C-2004	SGC-GAK-1 CAS:2226517-76-4	SGC-GAK-1 is a potent,selective,and cell-active inhibitor of cyclin G-associated kinase(GAK)with Ki value of 3.1nM and>50-fold selectivity over nearest kinase.	price>
R-C-2038	SR-3029 CAS：1454585-06-8	SR-3029 is a potent and ATP competitive CK1δand CK1ε inhibitor,with IC50s of 44nM and 260nM,respectively,and Kis of 97nM for both kinases.	price>
R-C-2042	Udenafil CAS：268203-93-6	Udenafil(DA8159)is a potent,selective and orally active phosphodiesterase type 5(PDE5)inhibitor.Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research.	price>

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