Product apis-metabolism

Home > products > apis> metabolism

Catalog	name	Description	price
R-C-2266	Pemetrexed (LY-231514) disodium CAS:150399-23-8	Pemetrexed(LY-231514)disodium is a novel antifolate and antimetabolite for TS,DHFR and GARFT with Ki of 1.3nM,7.2nM and 65nM in cell-free assays, respectively.Pemetrexed induces autophagy and apoptosis.	price>
R-C-2391	Methyldopa CAS: 555-30-6	Methyldopa is a centrally acting antihypertensive agent.It is metabolized to alpha-methylnorepinephrine in the brain,and this compound activates central alpha-2 adrenergic receptors.Being a selective agonist for α2 adrenergic receptors,psychoactive drug is used as a sympatholytic or antihypertensive.	price>
R-C-2434	Nodakenetin CAS:495-32-9	Nodakenetin(NANI),a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase,PTP1B,rat lens aldose reductase(RLAR),AChE,BChE,and β-site amyloid precursor protein cleaving enzyme 1(BACE1).Nodakenetin alters the protein expression of Bax and Bcl-2,and prompts mitochondrial apoptosis.Nodakenetin exhibits anti-tumor activity.	price>
R-C-2439	Edrophonium chloride CAS:116-38-1	Edrophonium Chloride,also known as Tensilon,is an acetylcholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. Edrophonium Chloride has also been used as an antidote to curare principles.	price>
R-C-2467	Cevimeline CAS:153504-70-2	Cevimeline(AF-102B)is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist.Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia.Cevimeline can cross the blood-brain barrier(BBB).	price>
R-C-2470	Irsogladine CAS:57381-26-7	Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.	price>
R-C-2487	Cobicistat (GS-9350) CAS:1004316-88-4	Cobicistat is a potent and selective inhibitor of cytochrome P450 3A(CYP3A) enzymes with IC50s of 30-285nM.Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.	price>
R-C-2488	Apremilast CAS:608141-41-9	Apremilast(CC-10004)is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase(PDE-4)with an IC50 of 74nM.Apremilast inhibits TNF-α release by lipopolysaccharide(LPS)with an IC50 of 104nM.	price>
R-C-2492	Indisulam (E 7070) CAS:165668-41-7	Indisulam(E 7070)is a carbonic anhydrase inhibitor with anticancer activity. Indisulam(E 7070)is a sulfonamide agent that targets the G1 phase of the cell cycle.Indisulam(E 7070)causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E.Indisulam(E 7070)targets splicing by inducing RBM39 degradation via recruitment to DCAF15.	price>
R-C-2514	Olprinone CAS:106730-54-5	Olprinone(Loprinone)is a potent phosphodiesterase(PDE)3 inhibitor,with IC50s of 150,100,0.35 and 14μM for PDE1,PDE2,PDE3 and PDE4,respectively.Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects.Anti-inflammatory activity.	price>

...