Product apis-metabolism

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Catalog	name	Description	price
R-C-2703	Sephin1 CAS:951441-04-6	Sephin1 is a selective inhibitor of a holophosphatase.Sephin1 selectively bound and inhibited the stress-induced PPP1R15A,but not the related and constitutive PPP1R15B,to prolong the benefit of an adaptive phospho-signaling pathway, protecting cells from otherwise lethal protein misfolding stress.	price>
R-C-2706	ML 228 CAS：1357171-62-0	ML228(CID-46742353)is a potent the Hypoxia Inducible Factor(HIF)pathway activator with EC50 of 1μM.ML228 potently activates HIF in vitro as well as its downstream target VEGF.	price>
R-C-2729	PF-04457845 CAS:1020315-31-4	PF-04457845 is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63nM and 7.4±0.62nM for hFAAH and rFAAH,respectively.	price>
R-C-2730	MK-8245 CAS:1030612-90-8	MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)with IC50 of 1 nM for human SCD1 and 3nM for both rat SCD1 and mouse SCD1,with anti-diabetic and anti-dyslipidemic efficacy.Phase 2.	price>
R-C-2734	A939572 CAS：1032229-33-6	A939572 is a potent,and orally bioavailable stearoyl-CoA desaturase1(SCD1)inhibitor with IC50 values of <4nM and 37nM for mSCD1 and hSCD1,respectively.	price>
R-C-2737	Indoximod (NLG-8189) CAS:110117-83-4	Indoximod(1-Methyl-D-tryptophan;NLG-8189)is an indoleamine 2,3-dioxygenase(IDO)pathway inhibitor with a Ki of 19μM.	price>
R-C-2738	Tunicamycin CAS:11089-65-9	Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase(GPT).Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum(ER)and induces ER stress,and causes blocking of DNA synthesis and cell cycle arrest in G1 phase.	price>
R-C-2741	TAK 21d CAS:1143578-94-2	TAK-21d is a potent FAAH Inhibitor.	price>
R-C-2745	nTZDpa CAS:118414-59-8	Potent,selective non-thiazolidinedione PPARγ partial agonist (EC50=57nM);produces~25% maximum efficacy.Antagonizes full agonist activity by ~60%(IC50~285nM).Displays no activity at PPARα or PPARδ receptors.	price>
R-C-2746	Isosafrole CAS:120-58-1	Isosafrole,a stiripentol analog,is a potent LDH inhibitor.Stiripentol is a new-generation antiepileptic drug,and its chemical structure is unrelated to other antiepileptic drugs.Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase(LDH),which is a component of the astrocyte-neuron lactate shuttle.	price>

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