Product apis-metabolism

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Catalog	name	Description	price
R-C-2515	Gimeracil CAS:103766-25-2	Gimeracil is a pyridine derivative with antitumor activity.Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.	price>
R-C-2516	Tadalafil CAS:171596-29-5	Tadalafil（IC351）is PDE5 inhibitor marketed in pill form for treating erectile dysfunction(ED)under the name Cialis,and under the name Adcirca for the treatment of pulmonary arterial hypertension.	price>
R-C-2517	NSC14613(PluriSln1) CAS:91396-88-2	PluriSln-1(NSC 14613)is pluripotent cell-specific inhibitor(PluriSIn).PluriSIn #1 induces ER stress,protein synthesis attenuation,and apoptosis in hPSCs. PluriSIn #1 was also cytotoxic to mouse blastocysts,indicating that the dependence on oleate is inherent to the pluripotent state.The use of human pluripotent stem cells(hPSCs)in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells.	price>
R-C-2518	AGI-6780 CAS:1432660-47-3	AGI-6780 is a potent and selective IDH2 inhibitor.AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q.Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.	price>
R-C-2519	Dimethyloxaloylglycine;DMOG CAS:89464-63-1	DMOG(Dimethyloxallyl Glycine)is a cell permeable and competitive inhibitor of HIF-PH,which results in HIF-1α stabilisation and accmulation in vitro and in vivo.DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases.DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal.DMOG induces cell autophagy.	price>
R-C-2520	Moclobemide CAS:71320-77-9	Moclobemide(Ro111163)is a brain-penetrant and reversible monoamine oxidase(MAO-A)inhibitor with an IC50 of 6.061μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.	price>
R-C-2521	Rosiglitazone CAS:155141-29-0	Rosiglitazone maleate(BRL 49653),a member of the thiazolidinedione class of antihyperglycaemic agents,is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ(PPAR-γ)with IC50 of 42nM.	price>
R-C-2522	PF3845 CAS:1196109-52-0	PF-3845 is a fatty acid amide hydrolase(FAAH)inhibitor,and acts in the nervous system to reverse LPS-induced tactile allodynia in mice.PF-3845 promotes neuronal survival,attenuates inflammation and improves functional recovery in mice with traumatic brain injury.	price>
R-C-2683	Leflunomide CAS:75706-12-6	Leflunomide(HWA486,RS-34821,SU101,Arava)is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD,used as an immunosuppressant agent.The active metabolite of Leflunomide is A77 1726,which inhibits dihydroorotate dehydrogenase (DHODH).Leflunomide is also an agonist of the AhR.	price>
R-C-2689	Calyculin A CAS：101932-71-2	Calyculin A is a natural,cell-permeable inhibitor of the serine-threonine protein phosphatases(PP)PP1 and PP2A(IC50s=0.3-0.7 and 0.5-1nM,respectively).It is without significant effect against PP2B,PP2C,and PP4.2 Through its effects on PP1 and PP2A,calyculin A has been shown to either promote or inhibit cancer cell growth in tumor cell lines and animal models.	price>

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