Product apis-metabolism

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Catalog	name	Description	price
R-C-2747	DASA-58 CAS:1203494-49-8	DASA-58 is a potent activator of pyruvate kinase M2(PKM2)with an AC90 of 680 nM, and an AC50 of 38nM.	price>
R-C-2749	PLP (139-151) CAS:122018-58-0	Synthetic myelin proteolipid protein(PLP)fragment.Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE),an animal model of multiple sclerosis.	price>
R-C-2754	Tolcapone CAS:134308-13-7	Tolcapone(Ro 40-7592)is a selective,orally active and powerful mixed(peripheral and central)COMT inhibitor with an IC50 of 773 nM in the liver.Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis.Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma.	price>
R-C-2755	Atorvastatin Calcium CAS:134523-03-8	Potent HMG-CoA reductase inhibitor(IC50=8 nM).Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.	price>
R-C-2756	VT-464 racemate CAS:1375603-36-3	Seviteronel racemate(VT-464 racemate)is the racemate form of Seviteronel(VT-464),which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.	price>
R-C-2757	Brinzolamide CAS:138890-62-7	Brinzolamide(AL 4862)is a potent carbonic anhydrase II inhibitor with IC50 of 3.19nM.	price>
R-C-2758	PF-4981517 CAS:1390637-82-7	CYP3cide(PF-4981517)is a potent,selective and time-dependent inhibitor of cytochrome P4503A4(CYP3A4).The IC50 values for Midazolam 1-hydroxylase activity are 0.03μM,17μM,and 71μM for CYP3A4,CYP3A5, and CYP3A7,respectively.CYP3cide can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism.	price>
R-C-2760	PACOCF3 CAS：141022-99-3	Phospholipase A2 inhibitor.	price>
R-C-2761	YM 26734 CAS：144337-18-8	YM-26734 is an inhibitor of rabbit platelet sPLA2.YM-26734 has been used to ameliorate local inflammatory responses in TPA-induced mouse ear edema.	price>
R-C-2762	GSK 2837808A CAS：1445879-21-9	GSK2837808A is a potent,selective lactate dehydrogenase A(LDHA)inhibitor(IC50 values are 1.9 and 14nM for LDHA and LDHB respectively).	price>

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