Product apis-metabolism

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Catalog	name	Description	price
R-C-2062	DS-1001b (DS 1001) CAS：1898207-64-1	DS-1001b is a mutant IDH-1(Isocitrate Dehydrogenase-1)inhibitor extracted from patent WO2016052697A1,Example 168,and has antitumor activity.	price>
R-C-2067	SR-18292 CAS：2095432-55-4	SR-18292 is a PPAR gamma coactivator-1α(PGC-1α)inhibitor,which increases PGC-1α acetylation,suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.	price>
R-C-2091	Firsocostat (GS-0976) CAS：1434635-54-7	Firsocostat(ND-630;GS-0976;NDI-010976)is an acetyl-CoA carboxylase(ACC) inhibitor;inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1nM, respectively.	price>
R-C-2095	BI-409306 CAS：1189767-28-9	BI 409306(SUB 166499)is a potent and selective inhibitor of human and rat PDE9A with mean IC50 of 65 nM and 168 nM,respectively.Treatment with BI 409306 increases brain cGMP levels,promotes long-term potentiation,and improves episodic and working memory performance in rodents.	price>
R-C-2122	KY-226 CAS：1621673-53-7	KY-226 is a potent,selective,orally active and allosteric protein tyrosine phosphatase 1B(PTP1B)inhibitor with an IC50 of 0.25 μM,and without PPARγ agonist activity.KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling,respectively.KY-226 also protects neurons from cerebral ischemic injury.	price>
R-C-2133	GSK-2894631A CAS：2101626-26-8	GSK2894631A is a hematopoietic PGD synthase(HPGDS)inhibitor.	price>
R-C-2144	TEPP-46 (ML265) CAS:1221186-53-3	TEPP-46(ML-265)is a potent and selective pyruvate kinase M2(PKM2)activator with an AC50 of 92nM,showing little or no effect on PKM1,PKL and PKR.	price>
R-C-2221	TCPOBOP CAS:76150-91-9	TCPOBOP is an agonist of the constitutive androstane receptor(CAR)(EC50=20nM). TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP),as dose-dependent direct agonist of CAR.	price>
R-C-2231	Trigonelline CAS： 535-83-1	Trigonelline,an alkaloid with potential antidiabetic activity,is present in considerable amounts in coffee.Trigonelline is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells.	price>
R-C-2243	Notoginsenoside R1 CAS：80418-24-2	Notoginsenoside R1(Sanchinoside R1),a saponin,is isolated from P.notoginseng. Notoginsenoside R1 exhibits anti-oxidation,anti-inflammatory,anti-angiogenic,and anti-apoptosis activities.Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion(I/R)injury.Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.	price>

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