Product apis-metabolism

Home > products > apis> metabolism

Catalog	name	Description	price
R-C-1662	URB602 CAS：565460-15-3	URB602 is an inhibitor of monoacylglycerol lipase(MGL),a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol(2-AG).	price>
R-C-1675	AR7 CAS:80306-38-3	AR7 is an atypical RARA/RARα(retinoic acid receptor,alpha)antagonist.AR7 specifically activates chaperone-mediated-autophagy(CMA)activity without affecting macroautophagy.	price>
R-C-1693	T0901317 CAS：293754-55-9	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5μM,respectively.T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM,respectively.T0901317 significantly suppresses cell proliferation and induces apoptosis.	price>
R-C-1711	BAY-876 CAS:1799753-84-6	BAY-876 is an orally active and selective glucose transporter 1 (GLUT1)inhibitor with an IC50 of 2 nM. BAY-876 is>130-fold more selective for GLUT1 than GLUT2,GLUT3,and GLUT4.BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth.	price>
R-C-1746	gw4064 CAS：278779-30-9	GW4064 is a selective,non-steroidal farnesoid X receptor(FXR)agonist(EC50=15nM).	price>
R-C-1752	RSL3 CAS：1219810-16-8	RSL3((1S,3R)-RSL3)is an inhibitor of glutathione peroxidase 4 (GPX4)(ferroptosis activator),reduces the expression of GPX4 protein,and induces ferroptotic death of head and neck cancer cell.RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.	price>
R-C-1756	LCI699 CAS：928134-65-0	Osilodrostat(LCI699)is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7nM, respectively.	price>
R-C-1762	metyrapone CAS：54-36-4	Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing is syndrome(hypercortisolism).It blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion,which in turn increases plasma 11-deoxycortisol levels.	price>
R-C-1806	(R)-GNE-140 CAS:2003234-63-5	(R)-GNE-140 is a potent lactate dehydrogenase A(LDHA)inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB,respectively;(R)-GNE-140 is 18-fold more potent than S enantiomer.	price>
R-C-1817	WZB117 CAS:1223397-11-2	WZB117 is an inhibitor of Glucose Transporter 1(GLUT1).It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10uM.	price>

...