Product apis-metabolism

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Catalog	name	Description	price
R-C-1344	Ezetimibe (SCH-58235） CAS：163222-33-1	Ezetimibe,also known as SCH 58235,is a drug that lowers plasma cholesterol levels.It acts by decreasing cholesterol absorption in the small intestine.It may be used alone when other cholesterol-lowering medications are not tolerated, or together with statins(ezetimibe/simvastatin)when statins alone do not control cholesterol.	price>
R-C-1353	Ezatiostat CAS:168682-53-9	Ezatiosta(TER199,TLK199,Telintra),a tripeptide analog of glutathione,is a peptidomimetic inhibitor of Glutathione S-transferase P1-1(GSTP1-1).Ezatiostat activates c-Jun NH2 terminal kinase(JNK1)and ERK1/ERK2 and induces apoptosis.	price>
R-C-1356	Ro 61-8048 CAS No. 199666-03-0	Ro61-8048 is a potent Kynurenine hydroxylase inhibitor(Ki=4.8 nM,IC50=37nM).Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.Ro 61-8048 may be potentially useful for the treatment of dyskinesias.Ro 61-8048 could be a new avenue to reduce neuronal loss in brain ischemia.	price>
R-C-1380	AM580 CAS:102121-60-8	AM-580 is a potent RARalpha agonist.AM580 has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells.AM580 inhibited the wnt pathway,measured by loss of nuclear beta-catenin,suggesting partial oncogene dependence of therapy.Am580 treatment increased RARbeta and lowered the level of RARgamma,an isotype whose expression we linked with tumor proliferation.	price>
R-C-1391	Deltarasin CAS：1440898-61-2	Deltazinone is highly potent and selective PDEδ inhibitor.Deltazinone exhibits less unspecific cytotoxicity than the previously reported Deltarasin and demonstrates a high correlation with the phenotypic effect of PDEδ knockdown in a set of human pancreatic cancer cell lines.	price>
R-C-1398	LY-2183240 CAS:874902-19-9	LY-2183240 is a potent,covalent inhibitor of the EC-degrading enzyme fatty acid amide hydrolase(FAAH).LY-2183240 disrupts the cellular uptake of the lipid endocannabinoid(EC)anandamide and promote analgesia in vivo.LY-2183240 is also an inhibitor of monoacylgylcerol lipase(MGL).	price>
R-C-1439	u-104 CAS：178606-66-1	U-104(SLC-0111)is a potent carbonic anhydrase(CA)inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM,respectively.U-104 shows a significant delay in tumor growth in mice model.	price>
R-C-1469	U104(NSC 213841/MST104) CAS:178606-66-1	U-104(MST-104,NSC 213841,SLC-0111,WBI-5111)is a potent carbonic anhydrase(CA) inhibitor for CA IX and CA XII with Ki of 45.1nM and 4.5nM,respectively,very low inhibition for CA I and CA II.	price>
R-C-1478	PF-2545920 CAS:1292799-56-4	Mardepodect(PF-2545920)is a potent,orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM,with>1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier.	price>
R-C-1508	LXR-623 (WAY-252623) CAS：875787-07-8	LXR-623(WAY-252623)is a novel liver X-receptor(LXR)agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β,respectively.It is orally bioavailable and readily passes the blood-brain barrier.	price>

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