Product apis-metabolism

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Catalog	name	Description	price
R-C-1520	TMS CAS:24144-92-1	TMS is a potent,selective and competitive inhibitor of cytochrome P450 1B1,an enzyme overexpressed in certain tumors(IC50=6 nM).5N/A-and 520-fold selective over P450 1A1 and 1A2 respectively.	price>
R-C-1523	AZ876 CAS:898800-26-5	AZ876 is a potent and high-affinity LXR agonist.AZ876 displays 25-fold and 2.5-fold more potent than GW3965(HY-10627)on human(h)LXRα and hLXRβ respectively.	price>
R-C-1539	Liproxstatin-1 CAS: 950455-15-9	Liproxstatin-1 is a potent inhibitor of ferroptosis,a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species(ROS).Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types,and in engineered cells overexpressing oncogenic RAS.	price>
R-C-1543	AZD7545 CAS：252017-04-2	AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2,respectively.It failed to inhibit PDHK4 at higher concentrations(>10 nM),AZD7545 stimulates PDHK4 activity.	price>
R-C-1555	shp099 CAS:1801747-42-1	SHP099 is a potent,selective,orally available SHP2 inhibitor with an IC50 of 70 nM.	price>
R-C-1561	AM-2394 CAS：1442684-77-6	AM-2394 is a potent and selective Glucokinase agonist(GKA),which catalyzes the phosphorylation of glucose to glucose-6-phosphate.AM-2394 activates GK with an EC50 of 60 nM,increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models,and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes.	price>
R-C-1573	ML348 CAS:899713-86-1	ML348 is a selective and reversible lysophospholipase 1(LYPLA1)inhibitor(IC50 =210nM),Exhibits 14-fold selectivity for LYPLA1 over LYPLA2,Also selective over a panel of ~30 other serine hydrolases.	price>
R-C-1576	VX497（Merimepodib） CAS：198821-22-6	Merimepodib(Merimempodib,MMPD,VI-21,497,VX-497)is a potent,specific,and reversible inosine monophosphate dehydrogenase(IMPDH)inhibitor with antiviral activity against hepatitis C virus(HCV)and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent.	price>
R-C-1614	BMS309403 CAS：300657-03-8	BMS-309403 is a potent,orally active and selective adipocyte fatty acid binding protein(also known as FABP4,aP2)inhibitor with Kis of <2,250,and 350 nM for FABP4,FABP3,and FABP5,respectively.BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids.BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.	price>
R-C-1644	TOFA (5-(Tetradecyloxy)-2-furoic acid） CAS:54857-86-2	TOFA(5-(Tetradecyloxy)-2-furoic acid,Tyrphostin 46,Tyrphostin A46,Tyrphostin B40)is an allosteric inhibitor of acetyl-CoA carboxylase-α(ACCA).Inside the cell,TOFA is converted to TOFyl-CoA(5-tetradecyloxy-2-furoyl-CoA),exerting an allosteric inhibition on ACCA.TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner.	price>

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