Product apis-metabolism

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Catalog	name	Description	price
R-C-1236	STF-118804 CAS: 894187-61-2	STF 118804 is a highly specific NAMPT inhibitor that reduces the viability of most B-ALL cell lines with high potency IC50 values in the low nanomolar range and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia.	price>
R-C-1245	u73122 CAS:112648-68-7	U-73122 is a potent phospholipase C inhibitor or PI-PLC inhibitor.U-73122 is widely used as a tool to investigate the involvement of the phosphoinositide-specific phospholipase C(PLC)in signal transduction,particularly in studies attempting to characterize pathways leading to intracellular Ca2+ mobilization upon agonist challenge.U-73122 directly blocks PLC isoenzymes in vivo and in vitro.	price>
R-C-1258	ZLN005 CAS No. 49671-76-3	ZLN005 is a PGC-1α Transcriptional Regulator,which shoed some beneficialfEffects on diabetic db/db mice.ZLN005 increased fat oxidation and improved the glucose tolerance, pyruvate tolerance,and insulin sensitivity of diabetic db/db mice.Hyperglycemia and dyslipidemia also were ameliorated after treatment with ZLN005.	price>
R-C-1268	GSK3787 CAS：188591-46-0	GSK-3787 is a selective and irreversible peroxisome proliferator-activated receptor delta(PPARdelta)antagonist with good pharmacokinetic properties. GSK3787 can antagonize PPARbeta/delta in vivo,thus providing a new strategy to delineate the functional role of a receptor with great potential as a therapeutic target for the treatment and prevention of disease.	price>
R-C-1276	CHS 828 CAS：200484-11-3	CHS-828(GMX1778)is a competitive inhibitor of nicotinamide phosphoribosyltransferase(NAMPT),with an IC50 less than 25 nM.CHS-828 (GMX1778)exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity.	price>
R-C-1280	AZ-33 CAS：1370290-34-8	AZ-33(LDHA Inhibitor 33)is a potent inhibitor of lactate dehydrogenase A (LDHA)with IC50 of 0.5 μM.LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	price>
R-C-1316	GSK0660 CAS:1014691-61-2	GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8(binding assay IC50 =155 nM;antagonist assay IC50=300nM)and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM.GSK0660(100nM)reduces CPT1a(a PPARβ/δ target gene)expression below the basal vehicle-treated level by approximately 50%,but shows no effect on PDK4 expression,which is also a PPARβ/δ target gene in skeletal muscle cells.GSK0660(0.5μM)reduces the levels of AMPK and eNOS phosphorylation,and BMP-2,Runx-2 mRNA expression in MC3T3-E1 cells.	price>
R-C-1318	CH-223191 CAS:301326-22-7	CH223191 is a potent and specific aryl hydrocarbon receptor(AhR)antagonist. CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor.2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD)is a widespread environmental pollutant with many toxic effects,including endocrine disruption,reproductive dysfunction,immunotoxicity,liver damage,and cancer. CH223191 potently inhibits TCDD-induced AhR-dependent transcription.In addition,CH-223191 blocked the binding of TCDD to AhR and inhibited TCDD-mediated nuclear translocation and DNA binding of AhR.These inhibitory effects of CH-223191 prevented the expression of cytochrome P450 enzymes,target genes of the AhR.CH-223191,may be a useful agent for the study of AhR-mediated signal transduction and the prevention of TCDD-associated pathology.	price>
R-C-1327	FIPI CAS：939055-18-2	FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC50s of 25 nM and 20 nM,respectively.	price>
R-C-1342	Epacadostat (INCB024360) CAS：1204669-58-8	Epacadostat,also known as INCB024360 or INCB24360,is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase(IDO1)with potential immunomodulating and antineoplastic activities.INCB024360 targets and binds to IDO1,an enzyme responsible for the oxidation of tryptophan into kynurenine.By inhibiting IDO1 and decreasing kynurenine in tumor cells,INCB024360 increases and restores the proliferation and activation of various immune cells,including dendritic cells(DCs),NK cells,and T-lymphocytes,as well as interferon(IFN)production,and a reduction in tumor-associated regulatory T cells (Tregs).	price>

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