Product apis-metabolism

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Catalog	name	Description	price
R-C-728	CP673451 CAS No. 924416-43-3	CP-673451 is a selective inhibitor of PDGFRα/βwith IC50 of 10 nM/1 nM in cell-free assays,exhibits >450-fold selectivity over other angiogenic receptors,has antiangiogenic and antitumor activity.	price>
R-C-736	Atglistatin CAS No. 1469924-27-3	Atglistatin is a highly potent,selective and competitive inhibitor of adipose triglyceride lipase(ATGL)with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro,but no toxicity up to a concentration of 50 μM.	price>
R-C-738	erastin CAS No. 571203-78-6	Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.	price>
R-C-751	BMS303141 cas: 943962-47-8	BMS303141 is a potent inhibitor of ATP citrate lyase(ACL).BMS303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM,and lowers plasma triglycerides in a murine hyperlipdemia model.	price>
R-C-759	LX1606 cas:1033805-22-9	LX 1606 is an orally bioavailable,small-molecule,tryptophan hydroxylase(TPH) inhibitor with potential antiserotonergic activity.	price>
R-C-986	(Obeticholic Acid)INT-747 CAS No. 459789-99-2	Obeticholic acid(INT-747)is a potent, selective and orally active FXR agonist with an EC50 of 99 nM.Obeticholic acid has anticholeretic and anti-inflammation effect.Obeticholic acid also induces autophagy.	price>
R-C-1089	D4476 CAS:301836-43-1	D4476 is a relatively specific cell osmotic inhibitor of CK1 and ALK5 with IC50 values of 0.3 and 0.5,respectively μ In vitro,the phosphorylation of CK1 (casein kinase 1)was located at the serine residue near another phosphoserine in the multipoint phosphorylation domain(MPD).D4476 may be a competitive ATP inhibitor of CK1.In H4IIE cells,the site-specific phosphorylation of FOXO1a (ser322 and ser325)was inhibited at 50 and 125 μ M.The initial rate of nuclear repulsion is reduced.In HeLa cells,d4476 inhibited CK1 induced RhoB phosphorylation(ser185)at 50℃μ RhoB dependent actin fiber formation is then activated.D4476 treaCAS No.285986-88-1t resulted in partial p53 dependent growth arrest of HCT116 cells.	price>
R-C-1102	4SC-101 CAS：717824-30-1	Vidofludimus is an orally bioavailable inhibitor of dihydroorotate dehydrogenase (DHODH),with potential anti-inflammatory,immunomodulating and anti-viral activities.Upon administration,vidofludimus specifically targets,binds to and prevents the activation of DHODH.This prevents the fourth enzymatic step in de novo pyrimidine synthesis,leading to inhibition of transcriptional elongation, cell cycle arrest,and apoptosis in activated lymphocytes.DHODH inhibition also leads to metabolic stress in activated lymphocytes and inhibition of the release of proinflammatory cytokines including interleukin (IL)-17(IL-17A and IL-17F) and interferon-gamma(IFNg),thereby reducing inflammation.In addition,DHODH inhibition may lead to host-based anti-viral activity against many viruses. DHODH,a mitochondrial enzyme that catalyzes the conversion of dihydroorotate (DHO) to orotate,is a key enzyme in pyrimidine de novo biosynthesis.	price>
R-C-1114	AC5216 CAS：226954-04-7	Emapunil(AC-5216,18 kiloDalton Translocator Protein,XBD173)is a novel mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO)ligand. Emapunil(AC-5216)showes high affinity for MBRs prepared from rat whole brain with Ki of 0.297 nM and IC50 of 3.04 nM and 2.73 nM at rat glioma cells and human glioma cells,respectively.	price>
R-C-1127	KPT 9274 ( ATG-019) CAS:1643913-93-2	KPT-9274,also known as PAK4-IN-1,is a potent,selective and dual PAK4/NAMPT inhibitor.KPT-9274 interferences with PAK4/NAMPT signaling pathways, which results in reduction of G2-M transit as well as induction of apoptosis and decrease in cell invasion and migration in several human RCC cell lines. Mechanistic studies demonstrate that inhibition of the PAK4 pathway by KPT-9274 attenuates nuclear β-catenin as well as the Wnt/β-catenin targets cyclin D1 and c-Myc.	price>

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