Product apis-metabolism

Home > products > apis> metabolism

Catalog	name	Description	price
R-C-1130	TAK063 CAS:1238697-26-1	TAK-063,also known as Balipodect.,is a highly potent,selective,and orally active phosphodiesterase 10A(PDE10A)inhibitor.TAK-063 is currently being evaluated in clinical trials for the treatment of schizophrenia.Phosphodiesterase 10A(PDE10A)is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons(MSNs)in the striatum.TAK-063 represents a promising drug for the treatment of schizophrenia with potential for superior safety and tolerability profiles.	price>
R-C-1137	Navoximod (GDC-0919, NLG-919) CAS：1402837-78-8	Navoximod(GDC-0919,NLG-919)is a potent inhibitor of IDO(indoleamine-(2,3)-dioxygenase)pathway with Ki of 7 nM and EC50 of 75 nM.	price>
R-C-1160	Anacetrapib (MK-0859) CAS:875446-37-0	Anacetrapib,also known as MK-0859,is a CETP inhibitor being developed to treat hypercholesterolemia(elevated cholesterol levels)and prevent cardiovascular disease.	price>
R-C-1162	BMS-687453 CAS:1000998-59-3	BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR)alpha agonist. with an EC(50)of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays.BMS-687453 demonstrated an excellent pharmacological and safety profile in preclinical studies and thus was chosen as a development candidate for the treatment of atherosclerosis and dyslipidemia.	price>
R-C-1185	Evacetrapib (LY2484595) CAS No. 1186486-62-3	Evacetrapib is a potent and selective of CETP inhibitor,which inhibits human recombinant CETP protein(IC50 5.5 nM)and CETP activity in human plasma(IC50 36 nM)in vitro.	price>
R-C-1187	SR9243 CAS :1613028-81-1	SR9243 is a potent and selective LXR inverse agonist.SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect.It induces cell death in multiple types of cancer and does not cause the side effects that have derailed previous attempts to target these processes.	price>
R-C-1198	SW-033291 CAS：459147-39-8	SW033291 is a potent and high-affinity inhibitor of 15-PGDH with a Ki of 0.1 nM.SW033291 increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 also promotes tissue regeneration.	price>
R-C-1201	JZL-195 CAS:1210004-12-8	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.	price>
R-C-1203	STF-31 CAS:724741-75-7	Glucose transporter 1(Glut1)is an inducible carrier of pentoses and hexoses, including glucose.STF-31 is an inhibitor of Glut1(IC50=~1 µM)that blocks glucose uptake.It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene,which overexpress Glut1.1 Although STF-31 binds Glut1, suggesting a direct effect,STF-31 also inhibits nicotinamide phosphoribosyltransferase,an enzyme that induces Glut1 expression.STF-31 is also toxic to human pluripotent stem cells(hPSCs)and can be used to selectively eliminate hPSCs from mixed cultures.	price>
R-C-1225	AG-221 CAS:1446502-11-9	Enasidenib is an oral,potent,reversible,selective inhibitor of the IDH2 mutant enzymes,with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K,respectively.	price>

...