Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4442	AMG 900 CAS No.945595-80-2	AMG 900/CAS No.945595-80-2 is a potent and highly selective pan-Aurora kinases inhibitor with IC50 of 5 nM, 4 nM and 1 nM for Aurora A, B and C, respectively.	price>
R-R-4443	ZM-447439 CAS No.331771-20-1	ZM-447439/CAS No.331771-20-1 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively.	price>
R-R-4444	LY3295668 CAS No.1919888-06-4	LY3295668 (AK-01)/CAS No.1919888-06-4 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.	price>
R-R-4445	PF-03814735 CAS No.942487-16-3	PF-03814735/CAS No.942487-16-3 is a potent, orally available, ATP-competitive and reversible aurora A and aurora B inhibitor with IC50s of 0.8 and 0.5 nM, respectively.	price>
R-R-4446	MLN8054 CAS No.869363-13-3	MLN8054/CAS No.869363-13-3 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM.	price>
R-R-4447	JB170 CAS No.2705844-82-0	JB170/CAS No.2705844-82-0 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.	price>
R-R-4448	BI-847325 CAS No.1207293-36-4	BI-847325/CAS No.1207293-36-4 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. BI-847325 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-4449	SP-96 CAS No.2682114-54-9	SP-96/CAS No.2682114-54-9 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC).	price>
R-R-4450	TCS7010 CAS No.1158838-45-9	TCS7010/CAS No.1158838-45-9 is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.	price>
R-R-4451	PF 477736 CAS No.952021-60-2	PF 477736 (PF 00477736)/CAS No.952021-60-2 is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.	price>

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