Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4451	PF 477736 CAS No.952021-60-2	PF 477736 (PF 00477736)/CAS No.952021-60-2 is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.	price>
R-R-4452	Ilorasertib hydrochloride CAS No.1847485-91-9	Ilorasertib (ABT-348) hydrochloride/CAS No.1847485-91-9 is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	price>
R-C-2753	SR 1664 CAS:1338259-05-4	SR1664 is a PPARγ antagonist.SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation(IC50=80nM;Ki=28.67nM).	price>
R-R-4453	SCH-1473759 hydrochloride CAS No.1094067-13-6	SCH-1473759 hydrochloride/CAS No.1094067-13-6 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.	price>
R-R-4454	CCT129202 CAS No.942947-93-5	CCT129202/CAS No.942947-93-5 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.	price>
R-R-4455	Chiauranib CAS No.1256349-48-0	Chiauranib (CS2164)/CAS No.1256349-48-0 is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects.	price>
R-R-4456	TAS-119 CAS No.1453099-83-6	TAS-119/CAS No.1453099-83-6 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.	price>
R-R-4457	PHA-680632 CAS No.398493-79-3	PHA-680632/CAS No.398493-79-3 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.	price>
R-R-4458	NU6140 CAS No.444723-13-1	NU6140/CAS No.444723-13-1 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively. Enhances the apoptotic effect, with anti-cancer activity.	price>
R-R-4459	CD532 hydrochloride CAS No.2926498-81-7	CD532 hydrochloride/CAS No.2926498-81-7 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.	price>

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