Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4452	Ilorasertib hydrochloride CAS No.1847485-91-9	Ilorasertib (ABT-348) hydrochloride/CAS No.1847485-91-9 is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).	price>
R-C-2753	SR 1664 CAS:1338259-05-4	SR1664 is a PPARγ antagonist.SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation(IC50=80nM;Ki=28.67nM).	price>
R-R-4453	SCH-1473759 hydrochloride CAS No.1094067-13-6	SCH-1473759 hydrochloride/CAS No.1094067-13-6 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.	price>
R-R-4454	CCT129202 CAS No.942947-93-5	CCT129202/CAS No.942947-93-5 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.	price>
R-R-4455	Chiauranib CAS No.1256349-48-0	Chiauranib (CS2164)/CAS No.1256349-48-0 is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects.	price>
R-R-4456	TAS-119 CAS No.1453099-83-6	TAS-119/CAS No.1453099-83-6 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.	price>
R-R-4457	PHA-680632 CAS No.398493-79-3	PHA-680632/CAS No.398493-79-3 is an aurora kinase inhibitor with IC50s of 27, 135 and 120 nM for aurora A, B and C, respectively.	price>
R-R-4458	NU6140 CAS No.444723-13-1	NU6140/CAS No.444723-13-1 is a selective CDK2-cyclin A inhibitor (IC50, 0.41 μM), exhibits 10- to 36-fold selectivity over other CDKs. NU6140 also potently inhibits Aurora A and Aurora B, with IC50s of 67 and 35 nM, respectively. Enhances the apoptotic effect, with anti-cancer activity.	price>
R-R-4459	CD532 hydrochloride CAS No.2926498-81-7	CD532 hydrochloride/CAS No.2926498-81-7 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.	price>
R-R-4460	DB0614 CAS No.2769753-47-9	DB0614 (Example 21)/CAS No.2769753-47-9 is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity.	price>

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