Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4461	ENMD-2076 Tartrate CAS No.1453868-32-0	ENMD-2076 Tartrate/CAS No.1453868-32-0 is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.	price>
R-R-4462	CCT241736 CAS No.1402709-93-6	CCT241736/CAS No.1402709-93-6 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM).	price>
R-R-4463	Aurora kinase inhibitor-3 CAS No.879127-16-9	Aurora kinase inhibitor-3/CAS No.879127-16-9 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50 of >10 μM. Aurora kinase inhibitor-3 has a binding mode with the cyclopropanecarboxylic acid moiety directed towards the solvent exposed region of the ATP-binding pocket.	price>
R-R-4464	dAURK-4 hydrochloride	dAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects.	price>
R-R-4465	AKI603 CAS No.1432515-73-5	AKI603/CAS No.1432515-73-5 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells.	price>
R-R-4466	Tinengotinib CAS No.2230490-29-4	Tinengotinib/CAS No.2230490-29-4 is the modulator of one or more protein kinases such as Aurora kinase and VEGFR kinase. Tinengotinib has the potential for the research of these kinase abnormalities diseases mediated, especially cancer-related diseases (extracted from patent WO2018108079A1).	price>
R-R-4467	Aurora kinase inhibitor-8 CAS No.2133001-88-2	Aurora kinase inhibitor-8/CAS No.2133001-88-2 is a highly selective inhibitor of the Aurora kinases.	price>
R-R-4468	TC-A 2317 hydrochloride CAS No.1245907-03-2	TC-A 2317 hydrochloride/CAS No.1245907-03-2 is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity.	price>
R-R-4469	Aurora Kinases-IN-3 CAS No.2840558-83-8	Aurora Kinases-IN-3 (Compound 15a)/CAS No.2840558-83-8 is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10.	price>
R-R-4470	SCH-1473759 CAS No.1094069-99-4	SCH-1473759/CAS No.1094069-99-4 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.	price>

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