Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4471	AAPK-25 CAS No.2247919-28-2	AAPK-25/CAS No.2247919-28-2 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM.	price>
R-R-4472	SJ3149 CAS No.3026986-17-1	SJ3149/CAS No.3026986-17-1 is a selective and potent degrader of CK1α protein in vitro and in vivo. SJ3149 has antitumor activity.	price>
R-R-4473	DEG-77 CAS No.3032265-06-5	DEG-77/CAS No.3032265-06-5, a PROTAC based IKZF2 and CK1α degrader, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h).	price>
R-R-4474	TMX-4116 CAS No.2766385-56-0	TMX-4116/CAS No.2766385-56-0 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.	price>
R-R-4475	Silmitasertib sodium salt CAS No.1309357-15-0	Silmitasertib sodium salt/CAS No.1309357-15-0 is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α.	price>
R-R-4476	TBB CAS No.17374-26-4	TBB/NSC 231634/Casein Kinase II Inhibitor I/CAS No.17374-26-4 is a cell-permeable and ATP-competitive CK2 inhibitor with an IC50 of 0.15 μM for rat liver CK2.	price>
R-R-4477	PF-4800567 CAS No.1188296-52-7	PF-4800567/CAS No.1188296-52-7 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM).	price>
R-R-4478	DMAT CAS No.749234-11-5	DMAT/CK2 Inhibitor/Casein kinase II Inhibitor/CAS No.749234-11-5 is a potent and specific CK2 inhibitor with an IC50 value of 130 nM.	price>
R-R-4479	FPFT-2216 CAS No.2367619-87-0	FPFT-2216/CAS No.2367619-87-0, a molecular glue compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase 1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease.	price>
R-R-4480	SSTC3 CAS No.1242422-09-8	SSTC3/CAS No.1242422-09-8 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.	price>

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