Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4431	Ro 90-7501 CAS No.293762-45-5	Ro 90-7501/CAS No.293762-45-5 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.	price>
R-R-4432	(S)-Ceralasertib CAS No.1352226-87-9	(S)-Ceralasertib ((S)-AZD6738)/CAS No.1352226-87-9 is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM. (S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics. (S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition.	price>
R-R-4433	AZ32 CAS No.2288709-96-4	AZ32/CAS No.2288709-96-4 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.	price>
R-R-4434	NU6027 CAS No.220036-08-8	NU6027/CAS No.220036-08-8 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.	price>
R-R-4435	Elimusertib-d3	Elimusertib-d3 (BAY 1895344-d3) is the deuterium labeled Elimusertib (BAY 1895344). Elimusertib is a potent, orally active and selective ATR inhibitor and has anti-tumor activity.	price>
R-R-4436	KU 59403 CAS No.845932-30-1	KU 59403/CAS No.845932-30-1 is a potent ATM inhibitor, with IC50 values of 3 nM, 9.1 μM and 10 μM for ATM, DNA-PK and PI3K, respectively.	price>
R-R-4437	SKLB-197 CAS No.2713577-16-1	SKLB-197/CAS No.2713577-16-1 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.	price>
R-R-4438	ATR-IN-4 CAS No.2574545-45-0	ATR-IN-4/CAS No.2574545-45-0 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13).	price>
R-R-4439	Tozasertib CAS No.639089-54-6	Tozasertib (VX 680; MK-0457)/CAS No.639089-54-6 is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.	price>
R-R-4440	JAB-2485 CAS No.2899209-55-1	JAB-2485/CAS No.2899209-55-1 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer.	price>

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