Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-C-2681	Amonafide CAS： 69408-81-7	Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.	price>
R-C-2682	CRT0044876 CAS：6960-45-8	CRT0044876 is a potent BER inhibitor or DNA Base Excision Repair Pathway Inhibitor (APE1 IC50-3 microM).CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds,with accumulation of apurinic sites.	price>
R-C-2694	BYK 204165 CAS：1104546-89-5	BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1(hPARP-1)with a pIC50 of 7.35(pKi=7.05),and murine PARP-2(mPARP-2)with a pIC50 of 5.38,respectively.BYK204165 displays 100-fold selectivity for PARP-1.	price>
R-R-4425	AZD1390 CAS No.2089288-03-7	AZD1390/CAS No.2089288-03-7 is a potent, highly selective, orally bioavailable, brain-penetrant ATM inhibitor with an IC50 of 0.78 nM in cell.	price>
R-R-4426	Camonsertib CAS No.2417489-10-0	Camonsertib (RP-3500)/CAS No.2417489-10-0 is an orally active, selective ATR kinase inhibitor (ATRi) with an IC50 of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC50=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity.	price>
R-C-2727	GSK 0660 CAS：1014691-61-2	GSK 0660 is a selective PPARβ antagonist(IC50 values are 0.155,>10 and≥10µM at PPARβ,PPARα and PPARγ respectively).	price>
R-R-4427	Elimusertib hydrochloride	Elimusertib (BAY 1895344) hydrochloride is a potent, orally active and selective ATR inhibitor with an IC50 of 7 nM. Elimusertib hydrochloride has anti-tumor activity. Elimusertib hydrochloride can be used for the research of solid tumors and lymphomas.	price>
R-R-4428	Gartisertib CAS No.1613191-99-3	Gartisertib (VX-803)/CAS No.1613191-99-3 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. Gartisertib potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity.	price>
R-R-4429	Tuvusertib CAS No.1613200-51-3	Tuvusertib (M1774; ATR inhibitor 1)/CAS No.1613200-51-3 is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.	price>
R-R-4430	Lartesertib CAS No.2495096-26-7	Lartesertib (M4076)/CAS No.2495096-26-7 is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1).	price>

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