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JB170 CAS No.2705844-82-0
JB170 CAS No.2705844-82-0
| Catalog # | Pkg Size | Price(USD) | Quantity | Buy this product |
|---|---|---|---|---|
| R-R-4447 | 5mg | 680.00 | + Add to cart |
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| R-R-4447 | 10mg | 1170.00 | + Add to cart |
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Product description
JB170/CAS No.2705844-82-0 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase.
| Appearance | N/A |
|---|---|
| Molecular Weight | 963.36 |
| Purity | >90% |
| CAS | 2705844-82-0 |
| Formula | C48H44ClFN8O11 |
| Storage | -20℃, protected from light and moisture |
| Transportation | 4-25℃ temperature for up to 2 weeks |
| Stability | 1 year |
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msds of JB170 CAS No.2705844-82-0 Related Product
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