Product apis-cell-cycle

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Catalog	name	Description	price
R-C-1464	TA 01 CAS:1784751-18-3	TA-01 is an inducer of cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction.	price>
R-C-1466	BMS-5 CAS:1338247-35-0	BMS-5(LIMKi 3)is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2,respectively.	price>
R-C-1467	BMS-3 CAS:1338247-30-5	BMS-3 is a LIM kinase 1(LIMK1)inhibitor.LIMK inhibition with 1μM BMS-3 damaged MTOC protein localisation to spindle poles,undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment.These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes.LIM kinase 1(LIMK1)activity is essential for cell migration and cell cycle progression.	price>
R-C-1477	bay1217389 CAS:1554458-53-5	BAY 1217389 is an orally bioavailable,selective inhibitor of the serine/threonine kinase monopolar spindle 1(Mps1)with IC50 values below 10 nmol/L while showing an excellent selectivity profile.	price>
R-C-1506	mps1in-2 CAS:1228817-38-6	Mps1-IN-2 is a potent,selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.	price>
R-C-1511	kobe0065 CAS：436133-68-5	Kobe0065 is a novel and effective inhibitor of Ras-Raf interaction, competitively inhibiting the binding of H-Ras GTP to c-Raf-1 RBD with a Ki value of 46±13 μM.	price>
R-C-1516	RS1 CAS:312756-74-4	RS-1 is a RAD51 activator,and also increases CRISPR/Cas9-mediated knock-in efficiencies.	price>
R-C-1548	Voruciclib CAS :1000023-04-0	Voruciclib is a flavone and cyclin dependent kinase(CDK)inhibitor with potential antineoplastic activity.	price>
R-C-1550	LY-3177833 CAS:1627696-51-8	LY-3177833 is a potent and selective inhibitor of CDC7(Cell Division Cycle 7-related Protein Kinase).	price>
R-C-1574	mpi-0479605 CAS：1246529-32-7	MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1.Cells treated with MPI-0479605 undergo aberrant mitosis,resulting in aneuploidy and formation of micronuclei.In cells with wild-type p53,this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway.In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis.Subsequently,cells undergo mitotic catastrophe and/or an apoptotic response.In xenograft models, MPI-0479605 inhibits tumor growth,suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.	price>

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