Product apis-cell-cycle

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Catalog	name	Description	price
R-C-451	GSK1070916 CAS:942918-07-2	GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/Cwith IC50 of 3.5 nM/6.5 nM.It displays 100-fold selectivity against the closely related Aurora A-TPX2 complex.	price>
R-C-454	Alisertib(MLN8237) CAS:1028486-01-2	Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay.It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest,apoptosis and autophagy.	price>
R-C-480	Roscovitine (Seliciclib) CAS:186692-46-6	Roscovitine (Seliciclib,CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM,0.7 μM and 0.16 μM in cell-free assays.It shows little effect on CDK4/6.	price>
R-C-481	sns032 CAS:345627-80-7	SNS-032(BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10-and 20-fold selective over CDK1/CDK4.It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6.SNS-032 (BMS-387032) induces apoptosi.	price>
R-C-487	Fasudil hydrochloride cas:105628-07-7	Fasudil Hydrochloride (HA-1077 Hydrochloride;AT877 Hydrochloride),is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1,IC50s of 0.158 μM and 4.58 μM,12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.Fasudil Hydrochloride is also a potent Ca2+channel antagonist and vasodilator.	price>
R-C-496	AZD5438 cas:602306-29-6	AZD-5438 is a potent CDK1,CDK2,and CDK9 inhibitor,with IC50s of 16 nM,6 nM,and 20 nM in cell-free assays,respectively.AZD-5438 shows less inhibition activity against GSK3β,CDK5 and CDK6 .	price>
R-C-497	CX-4945 CAS:1009820-21-6	Silmitasertib(CX-4945) is a potent and selective inhibitor of CK2(casein kinase 2)with IC50 of 1 nM in a cell-free assay,less potent to Flt3,Pim1 and CDK1 (inactive in cell-based assay).Silmitasertib induces autophagy and promotes apoptosis.	price>
R-C-520	MK-5108(VX689) cas:1010085-13-8	MK-5108(VX-689)is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C,while it inhibits TrkA with less than 100-fold selectivity.MK-5108 (VX-689) induces autophagy.	price>
R-C-532	R547 cas:741713-40-6	R547 is a novel,selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs)(Ki = 1,3,and 1 nM for CDK1,CDK2,and CDK4,respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.	price>
R-C-555	TAC-101 CAS:125973-56-0	Amsilarotene inhibits the phosphorylation of retinoblastoma gene product(RB) and increases the presence of 2 cyclin-dependent kinases(CDK)inhibitors resulting in cell cycle arrest.This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.	price>

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