Product apis-cell-cycle

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Catalog	name	Description	price
R-C-1154	BS-181 CAS:1397219-81-6	BS-181 is a highly selective CDK inhibitor for CDK7 with an IC(50)of 21 nmol/L. Testing of other CDKs as well as another 69 kinases showed that BS-181 only inhibited CDK2 at concentrations lower than 1 micromol/L,with CDK2 being inhibited 35-fold less potently(IC(50) 880 nmol/L)than CDK7.In MCF-7 cells,BS-181 inhibited the phosphorylation of CDK7 substrates,promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines,and showed antitumor effects in vivo.	price>
R-C-1176	MK1775 CAS：955365-80-7	Adavosertib is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity.Adavosertib selectively targets and inhibits WEE1,a tyrosine kinase that phosphorylates cyclin-dependent kinase 1(CDK1,CDC2)to inactivate the CDC2/cyclin B complex.Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.Unlike normal cells,most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells.	price>
R-C-1215	Inauhzin(INZ) CAS：309271-94-1	Inauhzin is a potent SIRT inhibitor,which effectively reactivates p53 by inhibiting SIRT1 activity,promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.	price>
R-C-1227	G007-LK CAS :1380672-07-0	G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2,with IC50s of 46 nM and 25 nM,respectively.	price>
R-C-1231	10058-F4 CAS No. 403811-55-2	10058-F4 is a potent and selective c-Myc inhibitor,which markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells.10058-F4 inhibits proliferation,downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells.10058-F4 induces cell-cycle arrest,apoptosis,and myeloid differentiation of human acute myeloid leukemia.	price>
R-C-1242	GSK269962A CAS:850664-21-0	GSK269962A(GSK 269962)is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively.GSK269962A has anti-inflammatory and vasodilatory activities.	price>
R-C-1251	TG003 CAS： 300801-52-9	TG003 is a potent and ATP-competitive Cdc2-like kinase(Clk)inhibitor with IC50 of 20 nM,200 nM,and 15 nM for Clk1,Clk2,and Clk4,respectively.No inhibitory effect on Clk3,SRPK1,SRPK2,or PKC.	price>
R-C-1267	Kenpaullone CAS：142273-20-9	Kenpaullone is a potent inhibitor of CDK1/cyclin B(IC50=400 nM),CDK2/cyclin A (IC50=680 nM),CDK2/cyclin E(IC50=7.5uM)and CDK5/p25(IC50=850 nM).Kenpaullone inhibits CDK2/cyclin A,CDK2/cyclin E and CDK5/cyclin/p35(IC50 values are 0.68, 7.5 and 0.85 μM respectively).	price>
R-C-1307	Prexasertib HCl (LY2606368) CAS：1234015-54-3	Prexasertib(LY2606368)is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L.For CHK2 and RSK,its IC50 values are 8 nM and 9 nM respectively in cell-free assay.	price>
R-C-1326	EHop-016 CAS：1380432-32-5	EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor.EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac,Rac-activated PAK1,lamellipodia formation,and cell migration.	price>

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