Product apis-cell-cycle

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Catalog	name	Description	price
R-C-1339	NU2058 CAS：161058-83-9	NU2058(O(6)-Cyclohexylmethylguanine)is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay.It also potentiates melphalan(DMF 2.3),and monohydroxymelphalan(1.7),but not temozolomide or ionising radiation.	price>
R-C-1341	PHA-767491HCL CAS：942425-68-5	PHA-767491,also known as CAY10572,is a potent,ATP-competitive dual cdc7/cdk9 inhibitor(IC50 values are 10 and 34 nM respectively)that prevents initiation of DNA replication.PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil.PHA-767491 in combination with 5-FU exhibited much stronger cytotoxicity and induced significant apoptosis manifested by remarkably increased caspase 3 activation and poly(ADP-Ribose)polymerase fragmentation in HCC cells.	price>
R-C-1346	4E1Rcat CAS：328998-25-0	4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.1 It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.1 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.	price>
R-C-1352	THZ1 CAS:1604810-83-4	THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM.THZ1 also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression.	price>
R-C-1376	10-deacetyl-7-xylosyl Paclitaxel CAS：90332-63-1	10-deactyl-7-xylosyl Paclitaxel is a disruptor of microtubules and derivative of paclitaxel that has been found in T.chinensis.It induces the disassembly of pig brain and Physarum microtubules in cell-free assays.10-deactyl-7-xylosyl Paclitaxel inhibits proliferation of,as well as induces cell cycle arrest at the G2/M phase and apoptosis in,PC3 prostate cancer cells.	price>
R-C-1409	BML-277 CAS:516480-79-8	Chk2 Inhibitor II(BML-277)is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM.It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases.Chk2 Inhibitor II(BML-277)dose dependently protects human CD4(+)and CD8(+)T-cells from apoptosis due to ionizing radiation.	price>
R-C-1414	Pyridostain CAS:1085412-37-8	Pyridostatin(RR82)is a G-quadruplex DNA stabilizing agent(Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication-and transcription-dependent DNA damage.Pyridostatin targets the proto-oncogene Src.Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.	price>
R-C-1426	TAK901 CAS:934541-31-8	TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B,respectively.	price>
R-C-1448	BML-210(CAY10433) CAS:537034-17-6	BML-210(CAY10433),is HDAC inhibitor.BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.BML-210 can inhibit cell growth and induce apoptosis in cervical cancer cells,what correlates with down-regulation of HDAC class I and II and changes in the DAPC expression levels.	price>
R-C-1463	Bohemine CAS:189232-42-6	Bohemine is a potent and selective,cell-permeable,cyclin-dependent kinase(CDK) inhibitor with IC50=1 µM.Bohemine is structurally similar to Olomoucine and Roscovitine.	price>

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