Product apis-cell-cycle

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Catalog	name	Description	price
R-C-1583	Alvespimycin	Alvespimycin is a heat shock protein 90(Hsp90)inhibitor and promising therapeutic agent for cancer.	price>
R-C-1591	ON123300 CAS:1357470-29-1	ON123300,a strong and brain-penetrant multi-kinase inhibitor, inhibits CDK4(IC50=3.9nM),Ark5(IC50=5nM),PDGFRβ(IC50=26 nM),FGFR1(IC50=26 nM),RET(IC50=9.2nM),and FYN(IC50=11nM).Single agent ON123300 causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors.ON123300 inhibits CDK6 with an IC50 of 9.82 nM.	price>
R-C-1601	K-Ras-IN-1 CAS:84783-01-7	K-Ras-IN-1 is a K-Ras inhibitor.K-Ras-IN-1 binds to K-Ras(WT),K-Ras(G12D),K-Ras(G12V),and H-Ras.K-Ras-IN-1 has potential for the research of pancreatic, colon and lung carcinomas.	price>
R-C-1609	ACY738 CAS:1375465-91-0	ACY-738 is a potent,selective and orally-bioavailable HDAC6 inhibitor,with an IC50 of 1.7 nM;ACY-738 also inhibits HDAC1,HDAC2,and HDAC3,with IC50s of 94,128,and 218 nM.	price>
R-C-1612	CXD101 CAS： 934828-12-3	CXD101 is a potent,selective and orally active class I HDAC inhibitor with IC50s of 63 nM,570 nM and 550 nM for HDAC1,HDAC2 and HDAC3, respectively.CXD101 has no activity against HDAC class II.CXD101 has antitumor activity.	price>
R-C-1620	HMN-214 CAS No. 173529-46-9	HMN-214 inhibits polo-like and cyclin-dependent kinase activity,has potent antimicrotubular effects and results in profound apoptosis and antitumor activity in a broad spectrum of human xenografts.	price>
R-C-1621	HMN-176 CAS No. 173529-10-7	HMN-176 is an active metabolite of HMN-214,which has a potent antitumor activity in mouse xenograft models.HMN-176 effectively inhibits PLK-1 by interference with its normal subcellular spatial distribution at centrosomes and along the cytoskeletal structure.	price>
R-C-1622	U93631 CAS:152273-12-6	U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid,time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.	price>
R-C-1623	ML141 CAS:71203-35-5	ML141(CID-2950007)is demonstrated to be a potent,selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases(Rac1,Rab2,Rab7).ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence.ML141 also protects neuroblastoma cells from metformin-induced apoptosis.	price>
R-C-1714	BGP-15 CAS:66611-37-8	BGP-15 is a PARP inhibitor,that can protect against heart failure and atrial fibrillation in mice.	price>

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