Product apis-cell-cycle

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Catalog	name	Description	price
R-C-1856	THZ531 CAS:1702809-17-3	THZ531 is a selective and covalent inhibitor of both CDK12 and CDK13 with IC50s of 158 nM and 69 nM.	price>
R-C-1872	JNJ7706621 CAS:443797-96-4	JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays.It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.	price>
R-C-1873	Mc-MMAE CAS:863971-24-8	Mc-MMAE is a protective group(maleimidocaproyl)-conjugated monomethyl auristatin E(MMAE),which is a potent tubulin inhibitor.Mc-MMAE is a drug-linker conjugate for ADC.	price>
R-C-1889	Sapacitabine CAS：151823-14-2	Sapacitabine is hydrolyzed by amidases to the deoxycytosine analogue CNDAC(2-Cyano-2-deoxyarabinofuranosylcytosine),which is then phosphorylated into the active triphosphate form.As an analogue of deoxycytidine triphosphate,CNDAC triphosphate incorporates into DNA strands during replication,resulting in single-stranded DNA breaks during polymerization due to beta-elimination during the fidelity checkpoint process; cell cycle arrest in the G2 phase and apoptosis ensue.	price>
R-C-2260	Dinaciclib (SCH727965) CAS：779353-01-4	Dinaciclib(SCH727965,PS-095760)is a novel and potent CDK inhibitor for CDK2,CDK5,CDK1 and CDK9 with IC50 of 1nM,1nM,3nM and 4nM in cell-free assays,respectively.It also blocks thymidine(dThd)DNA incorporation.Dinaciclib induces apoptosis through the activation of caspases 8 and 9.	price>
R-C-2261	Flavopiridol (L86-8275) CAS：146426-40-6	Flavopiridol(L86-8275,Alvocidib,NSC 649890,HMR-1275)competes with ATP to inhibit CDKs including CDK1,CDK2,CDK4,CDK6,and CDK9 with IC50 values in the 20-100nM range.It is more selective for CDK1,2,4,6,9 versus CDK7.Flavopiridol is initially found to inhibit EGFR and PKA.Flavopiridol induces autophagy and ER stress.Flavopiridol blocks HIV-1 replication.	price>
R-C-2262	LY3405105 CAS：2326428-25-3	LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8nM.LY3405105 shows potential antineoplastic activity.	price>
R-C-2263	BSJ-4-116 CAS：2519823-34-6	BSJ-4-116 is a highly potent and selective CDK12 degrader(PROTAC)with an IC50 of 6 nM.BSJ-4-116 downregulates DDR genes through a premature termination of transcription,primarily through increasing poly(adenylation).BSJ-4-116 exhibits potent antiproliferative effects,alone and in combination with the poly(ADP-ribose)polymerase inhibitor Olaparib(HY-10162).	price>
R-C-1904	M2I-1 CAS：312271-03-7	M2I-1 is an inhibitor of Mad2(mitotic arrest deficient 2)targeting the binding of Mad2 to Cdc20,an essential protein-protein interaction(PPI)within the SAC(spindle assembly checkpoint).	price>
R-C-2264	CC-671 CAS：1618658-88-0	CC-671 is a dual TTK protein kinase/CDC2-like kinase(CLK2)inhibitor with IC50s of 0.005 and 0.006μM for TTK and CLK2,respectively.	price>

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