Product apis-cell-cycle

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Catalog	name	Description	price
R-C-2108	LJ570 CAS：2252488-69-8	LJ570 is the first PPARα/γDual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. LJ570 is a potent partial agonist of both PPARα and γ subtypes.LJ570 inhibited the Cdk5-mediated phosphorylation of PPARγ at serine 273 that is currently considered the mechanism by which some PPARγ partial agonists exert antidiabetic effects similar to thiazolidinediones,without showing their typical side effects.LJ570 may be useful for treatment of dyslipidemic type 2 diabetes.	price>
R-C-2117	EOAI3402143 CAS：1699750-95-2	EOAI3402143 is a novel dose-dependent inhibitor of Usp9x and Usp24 activity, increasing tumor cell apoptosis and fully blocking or regressing myeloma tumors in mice.	price>
R-C-2135	NCC007 CAS：2342583-66-6	NCC007 is a dual casein kinase Iα(CKIα)and δ(CKIδ)inhibitor with IC50s of 1.8 and 3.6μM,respectively.NCC007 can be used in research of modulating mammalian circadian rhythms.	price>
R-C-2140	BMVC-8C3O CAS: 1301708-12-2	BMVC-8C3O is a DNA G-quadruplexe(G4)ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.	price>
R-C-2150	Ophiopogonin D CAS:945619-74-9	Ophiopogonin D,isolated from the tubers of Ophiopogon japonicus,is a rare naturally occurring C29 steroidal glycoside.Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation,IκBα down-regulation,intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells(HUVECs).	price>
R-C-2151	BTYNB CAS:304456-62-0	BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA(IC50=5 μM).BTYNB exhibits selectivity and effectiveness against IMP1-postive cancer cell lines.	price>
R-C-2191	Danusertib (PHA-739358) CAS:827318-97-8	Danusertib（PHA-739358)is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Aurora kinase inhibitor PHA-739358 binds to and inhibits the Aurora kinases,which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed.This agent may preferentially bind to and inhibit Aurora B kinase.Aurora kinases,a family of serine-threonine kinases,are important regulators of cellular proliferation and division.	price>
R-C-2288	THAL-SNS-032 CAS:2139287-33-3	THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon(CRBN).	price>
R-C-2227	Rigosertib (ON-01910) CAS:592542-59-1	Rigosertib(ON-01910)is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9nM in a cell-free assay.It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals.Rigosertib induces apoptosis in various cancer cells.	price>
R-C-2250	Cinobufagin CAS：470-37-1	Cinobufagin(Cinobufagine),an active ingredient of Venenum Bufonis,inhibits tumor development.Cinobufagin increases ATM and Chk2 and decreases CDC25C,CDK1,and cyclin B.Cinobufagin inhibits PI3K,AKT and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus,Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.	price>

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