Cinobufagin CAS：470-37-1

Cinobufagin(Cinobufagine),an active ingredient of Venenum Bufonis,inhibits tumor development.Cinobufagin increases ATM and Chk2 and decreases CDC25C,CDK1,and cyclin B.Cinobufagin inhibits PI3K,AKT and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus,Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.

msds---Cinobufagin