Product apis-cell-cycle

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Catalog	name	Description	price
R-C-2265	Ribociclib hydrochloride CAS：1211443-80-9	Ribociclib hydrochloride(LEE011 hydrochloride)is a highly specific CDK4/6 inhibitor with IC50 values of 10nM and 39nM,respectively,and is over 1,000-fold less potent against the cyclin B/CDK1 complex.	price>
R-C-2271	TK216 CAS:1903783-48-1	TK216 is an orally active and potent E26 transformation specific (ETS)inhibitor.TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions.TK216 blocks the binding between EWS-FLI1 and RNA helicase A.TK216 has anticancer activity.	price>
R-C-2272	GC7 Sulfate CAS:150417-90-6	GC7(N1-guanyl-1,7-diaminoheptane)Sulfate is an inhibitor of deoxyhypusine synthase(DHPS).GC7 inhibits Neuroblastoma(NB)cell proliferation in a dose-dependent manner,through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.	price>
R-C-2491	Gemcitabine elaidate（ CO-101,CP-4126） CAS:210829-30-4	Gemcitabine elaidate（CO-101 and CP-4126）is a lipophilic,unsaturated fatty acid ester derivative of gemcitabine (dFdC),an antimetabolite deoxynucleoside analogue,with potential antineoplastic activity.Upon hydrolysis intracellularly by esterases,the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate(dFdCDP and dFdCTP)by deoxycytidine kinase.dFdCDP inhibits ribonucleotide reductase,thereby decreasing the deoxynucleotide pool available for DNA synthesis;dFdCTP is incorporated into DNA,resulting in DNA strand termination and apoptosis.	price>
R-C-2501	SAR-020106 CAS：1184843-57-9	SAR-020106 is an ATP-competitive,potent,and selective CHK1 inhibitor with an IC50 of 13.3nM for human CHK1.SAR-020106 shows excellent selectivity over CHK2.SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3-to 29-fold in several colon tumor lines and in a p53-dependent fashion.SAR-020106 can enhance antitumor activity with selected anticancer drugs.	price>
R-C-2552	AZD7762 CAS:860352-01-8	AZD-7762 is a synthetic small molecule inhibitor of checkpoint kinases(Chks)with potential chemosensitizing activity.AZD7762 binds to and inhibits Chks,which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells,resulting in tumor cell apoptosis.This agent may enhance the cytotoxicity of DNA-damaging agents.Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication,Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.	price>
R-C-2553	RO3280 CAS:1062243-51-9	Ro3280 is a selective inhibitor of PLK1 with IC50 value of 3nM.Polo-like kinase 1 (PLK1)is an enzyme and plays an important role in regulating cell cycles as an early trigger for G2/M phase transition.	price>
R-C-2554	BI 2536 CAS:755038-02-9	BI-2563 is a small molecule compound with potential antineoplastic activities.BI 2536 binds to and inhibits Polo-like kinase 1(Plk1),resulting in mitotic arrest,disruption of cytokinesis,and apoptosis in susceptible tumor cell populations.Plk1,a serine/threonine-protein kinase,is a key regulator of multiple processes fundamental to mitosis and cell division.	price>
R-C-2564	Belumosudil (KD025, SLx-2119) CAS：911417-87-3	Belumosudil(KD025)is a selective inhibitor of ROCK2 with IC50s of 105nM and 24 µM for ROCK2 and ROCK1,respectively.Anti-fibrotic properties.	price>
R-C-2619	chroman 1 CAS:1273579-40-0	Chroman 1 is a highly potent and selective ROCK II inhibitor.	price>

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