Product apis-cell-cycle

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Catalog	name	Description	price
R-C-3000	Didox (NSC-324360) CAS:69839-83-4	Didox(nsc-324360)is a synthetic ribonucleotide reductase (RR) inhibitor.Only for scientific research, not for human body.	price>
R-C-2979	BAY-707 CAS：2109805-96-9	Bay-707 is a substrate competitive, efficient and selective inhibitor of MTH1 (NUDT1), with an IC50 value of 2.3 nm. Bay-707 has good pharmacokinetic characteristics compared with other MTH1 compounds and has good tolerance in mice, but the experiment obviously lacks anticancer effect in vitro or in vivo.Only for scientific research, not for human body.	price>
R-R-4814	Folinic acid CAS No.58-05-9	Folinic acid (Leucovorin)/CAS No.58-05-9 is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.	price>
R-R-4815	Proguanil CAS No.500-92-5	Proguanil/CAS No.500-92-5, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor.	price>
R-R-4816	Aminopterin CAS No.54-62-6	Aminopterin (4-Aminofolic acid)/CAS No.54-62-6, the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.	price>
R-R-4817	Metoprine CAS No.7761-45-7	Metoprine (BW 197U)/CAS No.7761-45-7 is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Metoprine is an antifolate and antitumor agent.	price>
R-R-4818	LSN 3213128 CAS No.1941211-99-9	LSN 3213128/CAS No.1941211-99-9 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity.	price>
R-R-4819	Pelitrexol CAS No.446022-33-9	Pelitrexol (AG 2037)/CAS No.446022-33-9 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice.	price>
R-R-4820	Methotrexate metabolite CAS No.19741-14-1	Methotrexate metabolite (DAMPA)/CAS No.19741-14-1, the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent. Methotrexate metabolite is an antimalarial agent, which inhibits the parasite growth with an IC50 of 446 nM against the antifolate-sensitive strain and 812 nM against the highly resistant strain under physiological folate conditions. Methotrexate metabolite is inactive against mammalian cells. Methotrexate metabolite is a minimal inhibitor of dihydrofolate reductase among metabolites of methotrexate .	price>
R-R-4821	Trimetrexate glucuronate CAS No.82952-64-5	Trimetrexate glucuronate (NSC 352122)/CAS No.82952-64-5 is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia.	price>

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