Product apis-cell-cycle

Home > products > apis> cell-cycle

Catalog	name	Description	price
R-C-1919	PJ34 CAS: 344458-19-1	PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110nM and 86nM, respectively.	price>
R-C-1961	HDAC8-IN-1（MDK-7933） CAS：1417997-93-3	MDK-7933(HDAC8-IN-1)is a HDAC8 inhibitor with an IC50 of 27.2nM in cancer cell lines.MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines(A549,H1299,and CL1-5).	price>
R-C-2016	NSC-23766 CAS：1177865-17-6	NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors(GEFs)with IC50 of ~50μM in a cell-free assay;does not inhibit the closely related targets,Cdc42 or RhoA.	price>
R-C-2036	Thiazovivin CAS ：1226056-71-8	Thiazovivin is a potent ROCK inhibitor,which can protect human embryonic stem cells.Thiazovivin improves the efficiency of iPSC generation.	price>
R-C-2041	Adagrasib (MRTX849) CAS：2326521-71-3	Adagrasib(MRTX849)is a potent,selective,and covalent KRASG12C inhibitor that exhibits favorable drug-like properties,selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling.	price>
R-C-2052	Ripasudil (K-115) CAS :887375-67-9	Ripasudil(K-115)is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2,respectively,used for the treatment of glaucoma and ocular hypertension.	price>
R-C-2074	CCT245737 CAS：1489389-18-5	CCT245737 is a potent, selective and orally active checkpoint kinase 1(CHK1) inhibitor.CCT245737 showed CHK1 IC50=1.3nM,CHK2 IC50=2440nM,G2 check point abrogation IC50=30nM.Mouse F(oral)=100%.CCT245737 demonstrated a favorable physicochemical,PK,and PD-efficacy profile.The serine-threonine kinase CHK1 is a critical component of the cellular response to DNA damage,especially the repair of DNA breaks arising during replication or caused by DNA damaging chemotherapies and ionizing radiation.	price>
R-C-2082	ars-1620 CAS：1698055-85-4	ARS-1620 is a potent,orally bioavailable covalent inhibitor of KRAS-G12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.	price>
R-C-2083	USP25 and 28 inhibitor AZ-1 CAS：2165322-94-9	USP25/28 inhibitor AZ1(AZ1)is an orally active,selective,noncompetitive, dual ubiquitin specific protease(USP)25/28 inhibitor with IC50s of 0.7μM and 0.6 μM,respectively.USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model.	price>
R-C-2090	G1T38 CAS：1628256-23-4	Lerociclib(G1T38)is a potent and selective inhibitor of CDK4/6,with IC50s of 1 nM,2nM for CDK4/CyclinD1 and CDK6/CyclinD3,respectively.	price>

...