Gemcitabine elaidate（ CO-101,CP-4126） CAS:210829-30-4

Gemcitabine elaidate（CO-101 and CP-4126）is a lipophilic,unsaturated fatty acid ester derivative of gemcitabine (dFdC),an antimetabolite deoxynucleoside analogue,with potential antineoplastic activity.Upon hydrolysis intracellularly by esterases,the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate(dFdCDP and dFdCTP)by deoxycytidine kinase.dFdCDP inhibits ribonucleotide reductase,thereby decreasing the deoxynucleotide pool available for DNA synthesis;dFdCTP is incorporated into DNA,resulting in DNA strand termination and apoptosis.

msds---Gemcitabine elaidate（ CO-101,CP-4126）