BSJ-4-116 CAS：2519823-34-6

BSJ-4-116 is a highly potent and selective CDK12 degrader(PROTAC)with an IC50 of 6 nM.BSJ-4-116 downregulates DDR genes through a premature termination of transcription,primarily through increasing poly(adenylation).BSJ-4-116 exhibits potent antiproliferative effects,alone and in combination with the poly(ADP-ribose)polymerase inhibitor Olaparib(HY-10162).

msds---BSJ-4-116