Product apis-cell-cycle

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Catalog	name	Description	price
R-C-1057	EHT 1864 2HCl CAS: 754240-09-0	EHT 1864 is an inhibitor of Rac family small GTPases.EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation.The Kd values are 40,50,60,and 230 nM for Rac1,Rac1b,Rac2 and Rac3,respectively.EHT 1864 also potently inhibits other Rac-dependent transformation processes,Tiam1- and Ras-mediated growth transformation.EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo.	price>
R-C-1064	LY2835219 CAS：1231929-97-7	LY2835219 mesylate is a potent and selective CDK4/6 dual inhibitor with potential antineoplastic activity.CDK4/6 dual inhibitor LY2835219 has been shown in vitro to be a selective ATP-competitive inhibitor of CDK4/6 that inhibits phosphorylation of the Rb tumor suppressor protein and thereby induces G1 cell cycle arrest.Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition,thereby arresting the cell cycle in the G1 phase,suppressing DNA synthesis and inhibiting cancer cell growth.LY2835219 is being investigated in a phase I clinical trial and in a clinical trial for the treatment of mantle cell lymphoma.	price>
R-C-1065	D-64131(sc-203908) CAS:74588-78-6	D-64131 is an orally active tubulin inhibitor,with an IC50 of 0.53 μM for tubulin polymerization.D-64131 has antimitotic activity.D-64131 can be used for cancer research.	price>
R-C-1070	SU9516 CAS：377090-84-1	SU9516 is a potent,selective cdk2 inhibitor.It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.	price>
R-C-1071	yk-4-279 CAS:1037184-44-3	YK-4-279 is a ETV1 inhibitor,which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.YK-4-279,prevents prostate cancer growth and metastasis in a mouse xenograft model.	price>
R-C-1080	VE821 CAS:1232410-49-9	VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.	price>
R-C-1090	CCG-1423 CAS：285986-88-1	CCG-1423 is a small-molecule inhibitor of RhoA transcriptional signaling.CCG-1423 potently(<1 mumol/L)inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells,and whereas it inhibits the growth of RhoC-overexpressing melanoma lines(A375M2 and SK-Mel-147)at nanomolar concentrations, it is less active on related lines(A375 and SK-Mel-28)that express lower levels of Rho.	price>
R-C-1116	RGB-286638 CAS： 784210-87-3	RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9,cyclin B1-CDK1,cyclin E-CDK2,cyclin D1-CDK4,cyclin E-CDK3,and p35-CDK5 with IC50s of 1,2,3,4,5 and 5 nM,respectively;also inhibits GSK-3β,TAK1,Jak2 and MEK1,with IC50s of 3,5,50,and 54 nM.	price>
R-C-1138	RO-3306 CAS：872573-93-8	RO-3306 has been shown to inhibit CDK1/cyclin B1 and CDK1/cyclin A.RO-3306 reversibly arrests human cells at the G2/M border of the cell cycle.RO-3306 allows for effective cell synchronization in early mitosis.	price>
R-C-1148	Purvalanol A CAS： 212844	Purvalanol A is a potent CDK inhibitor,which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.indicating that the activation of CDKs contributes to the c-Src transformation.Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2,and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2.Purvalanol A induced a strong G2-M arrest,whereas PP2 weakly acted on the G1-S transition.	price>

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