LY2835219 CAS：1231929-97-7

LY2835219 mesylate is a potent and selective CDK4/6 dual inhibitor with potential antineoplastic activity.CDK4/6 dual inhibitor LY2835219 has been shown in vitro to be a selective ATP-competitive inhibitor of CDK4/6 that inhibits phosphorylation of the Rb tumor suppressor protein and thereby induces G1 cell cycle arrest.Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition,thereby arresting the cell cycle in the G1 phase,suppressing DNA synthesis and inhibiting cancer cell growth.LY2835219 is being investigated in a phase I clinical trial and in a clinical trial for the treatment of mantle cell lymphoma.

msds---LY2835219