Product apis-cell-cycle

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Catalog	name	Description	price
R-C-742	USP7-USP47 cas:1247825-37-1	USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor,with EC50s of 0.42 μM and 1.0 μM,respectively.	price>
R-C-746	LEE011 cas:1211441-98-3	Ribociclib(LEE01)is a highly specific CDK4/6inhibitor with IC50 values of 10 nM and 39 nM,respectively,and is over 1,000-fold less potent against the cyclin B/CDK1 complex.	price>
R-C-747	APY29 cas:1216665-49-4	APY29,an ATP-competitive inhibitor,is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM.APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain.	price>
R-C-748	PTC-209 cas:315704-66-6	PTC-209 is a novel potent and selective BMI-1 inhibitor,targeting the BMI-1 self-renewal machinery with an IC50 of ~0.5 μM.	price>
R-C-755	PU-H71 cas:873436-91-0	PU-H71(NSC 750424)is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.	price>
R-C-982	TAK960 CAS:1137868-52-0	TAK-960 is an orally available,selective inhibitor of polo-like kinase 1 (PLK1),with an IC50 of 0.8 nM.TAK-960 also shows inhibitory activities against PLK2 and PLK3,with IC50s of 16.9 and 50.2 nM,respectively.TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.	price>
R-C-1019	XEN-445 CAS NO. 1515856-92-4	XEN-445 is a novel,highly selective and efficient endothelial lipase(EL) inhibitor.Its IC50 for hel,hlpl and HHL are 0.237 μm,20 μ m and 9.5 μm, respectively.It showed good characteristics of ADME and PK,and showed the effect of increasing plasma HDLC concentration in mice.	price>
R-C-1022	PD0332991（Palbociclib） CAS No. 571190-30-2	Palbociclib(PD 0332991)is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM,respectively.Palbociclib has the potential for ER-positive and HER2-negative breast cancer research.	price>
R-C-1036	MK8745 CAS No. 885325-71-3	MK-8745 is a novel Aurora-A specific inhibitor.It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.	price>
R-C-1055	4EGI-1 CAS:315706-13-9	4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM.4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1.4EGI-1 induces apoptosis.	price>

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