mpi-0479605 CAS：1246529-32-7

MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1.Cells treated with MPI-0479605 undergo aberrant mitosis,resulting in aneuploidy and formation of micronuclei.In cells with wild-type p53,this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway.In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis.Subsequently,cells undergo mitotic catastrophe and/or an apoptotic response.In xenograft models, MPI-0479605 inhibits tumor growth,suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics.

msds---mpi-0479605