Product fluorescent-dyes-No-ROS-Rox-derivatives

Home > products > fluorescent-dyes> No-ROS-Rox-derivatives

Catalog	name	Description	price
R-XASYS-00041	BMPO,cas:387334-31-8	BMPO(C10H17NO3,199.2) is a cyclic nitrone spin trap agent, it is a water-soluble white solid which makes BMPO purification easier than other spin trap agents. Even after prolonged storage at 220°C, there was no artificial signal formation from aqueous solutions containing BMPO (25–100 mM). BMPO offers several advantages over the existing spin traps in the detection and characterization of thiyl radicals, hydroxyl radicals, and superoxide anions in biological systems. One of the perceived advantages of BMPO is that the BMPO/•OOH adduct does not readily decay nonenzymatically to the BMPO/•OH adduct	price>
R-XASYS-00042	Calycosin-7-glucoside,cas:20633-67-4	Calycosin-7-O-β-D-glucoside(C22H22NO10,446.4), a melanin biosynthesis inhibitor, is isolated from the methanol extract of astragalus. IC50 value: 68 μM in inhibition of Tyrosinase Target:In vitro: Calycosin-7-O-β-d-glucoside showed a melanin biosynthesis inhibition zone in a culture plate of Streptomyces bikiniensis. Furthermore, 75.78 μM of calycosin-7-O-β-d-glucoside dramatically decreased 50% of the melanin content on Melan-a cells without any apparent cytotoxicity.	price>
R-XASYS-00043	Chamazulene,cas:529-05-5	Chamazulene(C14H16,184.3) is a terpene that has been found in chamomile (M. recutita) flowers and has anti-inflammatory and antioxidant activities.It reduces increases in matrix metalloproteinase-3 (MMP-3), MMP-9, COX-2, inducible nitric oxide synthase (iNOS), and p65 NF-κB levels in IL-1β-stimulated primary rat chondrocytes when used at a concentration of 10 µg/ml.	price>
R-XASYS-00044	Chicoric acid,cas:6537-80-0	Chicoric acid(C22H18O12,474.37) is a dicaffeoyl ester that has been found in C. intybus with diverse biological activities.Chicoric acid (50-200 μg/ml) dose-dependently reduces the viability of Caco-2 and HCT116 human colorectal cancer cells.It inhibits HIV integrase activities, including 3-processing of a DNA oligonucleotide and integration with template DNA (IC50s = 1.1 and 0.8 μM, respectively).Chicoric acid (0.5-10 μM) noncompetitively inhibits integration of HIV DNA by HIV integrase and, at concentrations greater than or equal to 5 μM, inhibits HIV entry into H9 cells.	price>
R-XASYS-00045	CMS121,cas:1353224-53-9	CMS121(C20H19NO3,321.4) is a substituted quinoline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay.CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively.	price>
R-XASYS-00046	Coenzyme Q10-d6,cas:110971-02-3	Coenzyme Q10-d6 (CoQ10-d6)(C59H84D6O4,869.4) is intended for use as an internal standard for the quantification of CoQ10 by GC- or LC-MS. CoQ10 is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands.	price>
R-XASYS-00047	Coenzyme Q2,cas:606-06-4	Coenzyme Q2(C19H26O4,318.4) is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. Forms of coenzyme Q with shorter isoprenoid chains, including coenzyme Q2, induce p53-dependent apoptosis in human B-cell acute lymphoblastoid leukemia BALL-1 cells.	price>
R-XASYS-00048	Coumarin Boronic Acid,cas:1357078-03-5	Coumarin boronic acid (CBA)(C9H7BO4,190) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s) and moderately faster rate than hypochlorous acid. Peroxynitrite oxidizes CBA into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.	price>
R-XASYS-00049	Coumarin Boronic Acid pinacolate ester,cas:190788-61-5	Coumarin boronic acid pinacolate ester (CBE)(C15H17BO4,272.1) is a more soluble form of coumarin boronic acid that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluorescent product 7-hydroxycoumarin (COH), which displays excitation/emission maxima of 332/470 nm, respectively.	price>
R-XASYS-00050	Cu-ATSP,cas:68341-12-8	Cu-ATSP(C18H18CuN6S2,446.1) is a copper-containing bis(thiosemicarbazone) complex with ferroptosis inhibitory activity.It traps peroxyl radicals in a cell-free assay when used at a concentration of 6 µM. Cu-ATSP inhibits ferroptosis induced by (1S,3R)-RSL3 in Pfa1 mouse embryonic fibroblasts (MEFs) and HT22 mouse hippocampal cells (EC50s = 8.5 and 16 nM, respectively). It increases intracellular copper levels but, unlike the bis(thiosemicarbazone) complexes Cu-CQ2 and CuNC2, does not reduce amyloid-β (1-40) (Aβ40) levels in CHO cells overexpressing amyloid precursor protein (APP).	price>

...