Product fluorescent-dyes-No-ROS-Rox-derivatives

Home > products > fluorescent-dyes> No-ROS-Rox-derivatives

Catalog	name	Description	price
R-XASYS-00021	4-carboxy TEMPO,cas:37149-18-1	4-carboxy TEMPO(C10H18NO3,200.3) is a nitroxide and spin label. Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo., It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes.	price>
R-XASYS-00022	4-hydroperoxy Cyclophosphamide,cas:39800-16-3	4-hydroperoxy Cyclophosphamide (4-OOH-CY)(C7H15Cl2N2O4P,293.1) is the active metabolite form of the prodrug Cyclophosphamide. 4-OOH-CY crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS).Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders.	price>
R-XASYS-00023	4-hydroxy Alternariol,cas:959417-21-1	4-hydroxy Alternariol(C14H10O6,274.2) is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 uM under cell-free conditions.	price>
R-XASYS-00024	5-(3,4-Dihydroxyphenyl)-γ-Valerolactone,cas:21618-92-8	5-(3,4-Dihydroxyphenyl)-y-valerolactone(C11H12O4,208.2) is an active metabolite of various polyphenols, including (-)-epicatechin and procyanidin .It is formed from these polyphenols by gut microbiota. 5-(3,4-Dihydroxyphenyl)-γ-valerolactone is an inhibitor of matrix metalloproteinase-1 (MMP-1) and MMP-2 collagen degradation activity (IC50s = 108 and 106 nM, respectively), MMP-1 and MMP-9 gelatin degradation activity (IC50s = 45.2 and 17.7 nM, respectively), and MMP-2 and MMP-9 elastin degradation activity (IC50s = 61.8 and 89 nM, respectively).It also scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.	price>
R-XASYS-00025	5-Feruloylquinic Acid,cas:40242-06-6	5-Feruloylquinic acid(C17H20O9,368.3) is a chlorogenic acid that has been found in green coffee beans and has antioxidant activity.It scavenges DPPH and superoxide anion radicals in cell-free assays (IC50s = ~9 and ~36 µM, respectively).	price>
R-XASYS-00026	5-Heneicosylresorcinol,cas:70110-59-7	5-Heneicosylresorcinol(C27H48O2,404.7) is an alkylresorcinol that has been found in wheat, rye, triticale, and barley.It reduces hydrogen peroxide-induced DNA damage in HT-29 cells when used at a concentration of 100 μmol/L.2 5-Heneicosylresorcinol (160 μg/ml), when used in combination with 5-nonadecanoylresorcinol, inhibits migration and invasion, reduces the number of LC3 puncta, a marker of autophagy, and decreases survival in HepG2 cells.	price>
R-XASYS-00027	5-Tricosylresorcinol,cas:70110-60-0	5-Tricosylresorcinol(C29H52O2,432.7) is an alkylresorcinol that has been found in wheat, rye, triticale, and barley.It reduces hydrogen peroxide-induced DNA damage in HT-29 cells when used at a concentration of 100 μM.	price>
R-XASYS-00028	6-Methylpterin,cas:708-75-8	6-Methylpterin(C7H7N5O,177.2) is a derivative of the essential B vitamin folic acid .It generates singlet oxygen and hydrogen peroxide when exposed to photoirradiation in cell-free assays.6-Methylpterin has been used as an internal standard for the detection of pterins in urine.	price>
R-XASYS-00029	6α-hydroxy Cholesterol,cas:41083-73-2	6α-hydroxy Cholesterol(C27H48O2,404.7) is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.	price>
R-XASYS-00030	7,3,4-Trihydroxyflavone,cas:2150-11-0	7,3,4-Trihydroxyflavone(C15H10O5,270.2) is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 μM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 μM).7,3,4-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 μM).It is active against M. tuberculosis (MIC = 50 μg/ml).It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs)	price>

...