5-(3,4-Dihydroxyphenyl)-γ-Valerolactone,cas:21618-92-8

5-(3,4-Dihydroxyphenyl)-y-valerolactone(C11H12O4,208.2) is an active metabolite of various polyphenols, including (-)-epicatechin and procyanidin .It is formed from these polyphenols by gut microbiota. 5-(3,4-Dihydroxyphenyl)-γ-valerolactone is an inhibitor of matrix metalloproteinase-1 (MMP-1) and MMP-2 collagen degradation activity (IC50s = 108 and 106 nM, respectively), MMP-1 and MMP-9 gelatin degradation activity (IC50s = 45.2 and 17.7 nM, respectively), and MMP-2 and MMP-9 elastin degradation activity (IC50s = 61.8 and 89 nM, respectively).It also scavenges free radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.

msds of 5-3-4-dihydroxyphenyl-y-valerolactone