Product fluorescent-dyes-No-ROS-Rox-derivatives

Home > products > fluorescent-dyes> No-ROS-Rox-derivatives

Catalog	name	Description	price
R-XASYS-00001	β-Elemonic Acid,CAS:28282-25-9	β-Elemonic acid(C30H46O3,454.7) is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.	price>
R-XASYS-00002	(±)13-HpODE,CAS:23017-93-8	(±)13-HpODE (C18H32O4,312.4) is a racemic mixture of hydroperoxides derived non-enzymatically from linoleic acid through the action of reactive oxygen species. Lipid hydroperoxides, including 13-HpODE, have limited direct biological actions, such as the activation of lipoxygenases.Normally, (±)13-HpODE is rapidly reduced to (±)13-HODE, a compound which exhibits many biological activities.Importantly, 13-HpODE can also be metabolized to unsaturated aldehydes that can, in turn, covalently bind to DNA, amino acids, and proteins.	price>
R-XASYS-00003	(-)-FINO2,CAS:869298-31-7	(-)-FINO2(C15H28O3,256.4) is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron.It decreases GPX4 activity and protein levels in vitro but does not act as an active site, allosteric, or covalent inhibitor of GPX4 or alter GPX homeostasis.	price>
R-XASYS-00004	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine,cas:1000672-89-8	(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine(CSTMP) (C15H15ClN2,258.8) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs.	price>
R-XASYS-00005	(E/Z)-GSK5182	(E/Z)-GSK5182(C27H31NO3,417.54) is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC of 79 nM. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma.	price>
R-XASYS-00006	1,3,7-Trimethyluric Acid,cas:5415-44-1	1,3,7-Trimethyluric(C8H10N4O3,210.2) acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes. It can be detected in urine as a marker of caffeine consumption.	price>
R-XASYS-00007	1,3,7-Trimethyluric Acid-d9,cas:117490-42-3	1,3,7-Trimethyluric acid-d9(C8HD9N4O3,219.2) is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine .1 It is formed from caffeine by the cytochrome P450 (CYP) isoform CYP3A4. 1,3,7-Trimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.	price>
R-XASYS-00008	1,3-Dicaffeoylquinic acid,cas:19870-46-3	1,5-Dicaffeoylquinic acid (1,5-DCQA) (C25H24O12,516.45) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger.1,5-DCQA inhibits HIV-1 integrase 3 end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively.It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe in a dose-dependent manner.It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes.	price>
R-XASYS-00009	1-Hydroxyphenazine,cas:528-71-2	1-Hydroxyphenazine(C12H8N2O,196.2) is a phenazine pigment and virulence factor produced by P. aeruginosa.It increases production of reactive oxygen species (ROS) in RAW 264.7 cells in a concentration-dependent manner.1-Hydroxyphenazine (≥1.55 and ≥3.12 μM) increases release of elastase and myeloperoxidase (MPO), respectively, by human neutrophils activated with N-formyl-L-methionyl-L-leucyl-L-phenylalanine and cytochalasin B.It reduces ciliary beat frequency in isolated guinea pig tracheal rings, resulting in ciliary dyskinesia by 1 hour when used at concentrations of 10, 50, and 100 μM and ciliary stasis by 5 hours at 50 and 100 μM.1-Hydroxyphenazine reduces tracheal mucus velocity in anesthetized guinea pigs when administered as a 100 or 200 ng bolus dose. It is also active against the plant pathogenic fungi F. graminearum, P. grisea, A. solani, F. oxysporium, and S. sclerotiorum (MICs = 2-50 μg/ml)	price>
R-XASYS-00010	1-O-Hexadecyl-sn-glycerol,cas:506-03-6	1-O-Hexadecyl-sn-glycerol(C19H40O3,316.5) is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E2 in normal human epidermal keratinocytes (NHEKs). 1-O-Hexadecyl-sn-glycerol (50 μM) increases coronary flow and left ventricular developed pressure and reduces malondialdehyde (MDA) formation ex vivo in a rat heart model of ischemia/reperfusion injury.	price>

...