1,3-Dicaffeoylquinic acid,cas:19870-46-3

1,5-Dicaffeoylquinic acid (1,5-DCQA) (C25H24O12,516.45) has been found in A. montana and is an HIV-1 integrase inhibitor and free radical scavenger.1,5-DCQA inhibits HIV-1 integrase 3 end processing, end joining, and disintegration with IC50 values of 0.35, 0.56, and 0.84 μg/ml, respectively.It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an ED50value of 2 μg/ml. 1,5-DCQA (0.25-1 μM) reduces the level of free radicals released from human polymorphonuclear (PMN) cells stimulated by N-formyl-Met-Leu-Phe in a dose-dependent manner.It also dose-dependently increases cell survival and glutathione (GSH) levels and decreases reactive oxygen species (ROS) production and lactate dehydrogenase (LDH) release in an oxygen-glucose deprivation/reperfusion assay in rat cerebral astrocytes.

msds of 1-3-dicaffeoylquinic-acid