(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine,cas:1000672-89-8

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine(CSTMP) (C15H15ClN2,258.8) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs.

msds of e-2-2-chlorostyryl-3-5-6-trimethylpyrazine