Product fluorescent-dyes-No-ROS-Rox-derivatives

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Catalog	name	Description	price
R-XASYS-00011	1-Oleoyl-2-Palmitoyl-rac-glycerol,cas:3331-34-8	1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP)(C37H70O5,595) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. It enhances the inhibition of superoxide anion production by cytochalasin B when used at a concentration of 10 µM. The concentration of 1,2-OP decreases from 25.7 to 11.15% during the dry-curing process of Iberian ham.	price>
R-XASYS-00012	10-methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate),cas:161006-14-0	10-methyl-9-(phenoxycarbonyl) Acridinium9(C21H16NO2•CF3O3S,463.4) is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions. Acridinium salts, including 10-methyl-9-(phenoxycarbonyl) acridinium, can be used in chemiluminescence assays, enzyme, antigen, antibody, and hormone immunoassays, and assays to detect oxidants in environmental, biological, and pharmaceutical samples.	price>
R-XASYS-00013	10-Nitrooleate,cas:875685-46-4	Nitrated(C18H33NO4,327.5) unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo. Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.	price>
R-XASYS-00014	2,5-Dihydroxycinnamic Acid phenethyl ester,cas:179691-97-5	2,5-Dihydroxycinnamic acid phenethyl ester(C17H16O4,284.3) is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 μM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin .1 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 μM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 μM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 μM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 μM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.	price>
R-XASYS-00015	2S-Eriodictyol,cas:552-58-9	2S-Eriodictyol(C15H12O6,288.3) a flavanone that has been found in Citrus and has antioxidant activity.It is protective against hydrogen peroxide-induced cell injury and apoptosis in EA.hy926 cells when used at a concentration of 20 µM.	price>
R-XASYS-00016	3-(3-Hydroxyphenyl)propionic Acid sulfate,cas:86321-32-6	3-(3-Hydroxyphenyl)propionic acid (3-HPPA) sulfate(C9H10O6S,246.2) is a metabolite of a variety of phenols, including ferulic acid , dihydroferulic acid, and dihydrocaffeic acid , and the glycosides echinacoside and acteoside.Urinary excretion of 3-HPPA sulfate is reduced in protein-deficient mice infected with C. parvum and increased in mice fed wheat bran or functionalized wheat bran.	price>
R-XASYS-00017	3-acetyl-11-keto-β-Boswellic Acid,cas:67416-61-9	3-acetyl-11-keto-β-Boswellic Acid, as known as AKBA, is a pentacyclic triterpene that suppresses 5-lipoxygenase in a selective, nonredox, enzyme-directed, and noncompetitive manner. Also, AKBA inhibits topoisomeraseⅠand NF-kB signaling. AKBA has been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.	price>
R-XASYS-00018	3-Aminosalicylic Acid,cas:570-23-0	3-Aminosalicylic acid(C7H7NO3,153.1) is a salicylic acid derivative and potential impurity in commercial preparations of 5-aminosalicylic acid.It protects against apoptosis, as well as reverses reductions in mitochondrial complex I, also known as NADH dehydrogenase, activity and increases in reactive oxygen species (ROS) production induced by manganese in SK-N-MC cells when used at a concentration of 1 µM	price>
R-XASYS-00019	3-Demethylcolchicine,cas:7336-33-6	3-demethyl Colchicine is an active metabolite of colchicine .It suppresses antibody production induced by sheep red blood cells in co-culture with isolated mouse spleen cells when used at concentrations ranging from 0.1 to 10 ?g/ml.3-demethyl Colchicine (100 ?g/animal) inhibits carrageenan-induced paw edema in rats.	price>
R-XASYS-00020	3-Hydroxyterphenyllin,cas:66163-76-6	3-Hydroxyterphenyllin(C20H18O6,354.4) is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively)	price>

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