7,3,4-Trihydroxyflavone,cas:2150-11-0

7,3,4-Trihydroxyflavone(C15H10O5,270.2) is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 μM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 μM).7,3,4-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 μM).It is active against M. tuberculosis (MIC = 50 μg/ml).It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs)

msds of 7-3-4-trihydroxyflavone