Product fluorescent-dyes-No-ROS-Rox-derivatives

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Catalog	name	Description	price
R-XASYS-00051	Cu-GTSM,cas:68341-14-0	Cu-GTSM(C6H10CuN6S2,293.9) is a copper-containing compound and an analog of Cu-ATSM that has diverse biological activities.It is active against methicillin-sensitive and -resistant S. aureus clinical isolates (IC50s = 0.3-0.6 µM for all).Cu-GTSM inhibits the growth of SK-N-MC neuroepithelioma cells and MRC-5 fibroblasts (IC50s = 0.009 and 0.27 µM, respectively).	price>
R-XASYS-00052	Cyanidin 3-O-arabinoside,cas:792868-19-0	Cyanidin 3-O-arabinoside(C20H19O10,419.4) is an anthocyanin antioxidant that has been found in eggplant. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.	price>
R-XASYS-00053	CYM 5478,Cas:870762-83-7	CYM 5478(C21H19F3N2O2,388.4) is a sphingosine-1-phosphate receptor 2 (S1P2) agonist (EC50 = 0.78 μM in a reporter assay).1 It is selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin in C6 cells when used at a concentration of 10 μM.	price>
R-XASYS-00054	CYPMPO,cas:934182-09-9	CYPMPO(C10H18NO4P,247.2) is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.The high melting point (126°C), low hygroscopic properties, and long shelf-life in aqueous solutions offer significant practical advantages for use of CYPMPO over DEPMPO and DMPO.	price>
R-XASYS-00055	D-α-Tocopheryl Quinone,cas:7559-04-8	D-α-Tocopheryl quinone(C29H50O3,446.7) is an active oxidative metabolite of vitamin E and an essential cofactor for mitochondrial fatty acid desaturases.It has antioxidant activity in oxygen radical absorbance capacity (ORAC) and radical trapping assays when used at a concentration of 25 µM and inhibits ferroptosis induced by (1S,3R)-RSL3 in Q7 cells (EC50 = 0.233 µM).D-α-Tocopheryl quinone (20 mg/kg) decreases serum malondialdehyde (MDA) and blood glucose levels and restores the number and diversity of intestinal microflora in a rat model of high cholesterol and cholate diet-induced non-alcoholic steatohepatitis (NASH).	price>
R-XASYS-00056	DEPMPO,cas:157230-67-6	DEPMPO(C9H18NO4P,235.2) is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide. DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO.A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2•- does not produce the OH• adduct, which can be a drawback when using DMPO.	price>
R-XASYS-00057	DEPMPO-biotin,cas:936224-52-1	DEPMPO-biotin(C24H42N5O8PS,591.7) is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts. The biotin moiety offers an effective means for monitoring biodistribution in cells, tissues, and organs when used with an avidin-conjugated reporter. Importantly, DEPMPO-biotin binds free radicals, such as S-nitroso groups, on proteins, producing adducts that can be analyzed via the biotin tag. This direct labeling of S-nitrosothiols (SNO) thus serves as an effective alternative to the more cumbersome biotin-switch method for monitoring SNO formation.	price>
R-XASYS-00058	Diapocynin,cas:29799-22-2	Diapocynin(C18H18O6,330.3) is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91phox mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs). It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A2 (iPLA2) function, and reduces Ca2+ influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy. Diapocynin also reverses motor coordination deficits in the LRRK2R1441G mouse model of early Parkinsons disease.	price>
R-XASYS-00059	Dieugenol,cas:4433-08-3	Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities.It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays.It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s = 15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.	price>
R-XASYS-00060	Dihydrolipoic Acid,cas:462-20-4	Dihydrolipoic acid (DHLA)(C8H16O2S2,208.3) is a dithiol-containing carboxylic acid that is the reduced form of α-lipoic acid . It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including hydroxyl radicals, peroxynitirite, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM. At concentrations of 50-100 µM, DHLA triggers apoptosis of mouse embryonic stem cells and human cancer cells, suppressing proliferation.	price>

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